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ibuprofen suppositories
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever. Used for Fever reduction, Mild to moderate pain, Inflammation.
At a glance
| Generic name | ibuprofen suppositories |
|---|---|
| Sponsor | Soroka University Medical Center |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Inflammation, Fever |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammatory responses, pain signaling, and fever regulation. The suppository formulation delivers ibuprofen rectally for systemic absorption, providing an alternative route of administration particularly useful in patients unable to take oral medication.
Approved indications
- Fever reduction
- Mild to moderate pain
- Inflammation
Common side effects
- Gastrointestinal irritation
- Dyspepsia
- Nausea
- Rectal irritation (suppository formulation)
- Headache
- Dizziness
Key clinical trials
- The Effect of Pre-emptive Analgesia on the Postoperative Pain in Children Undergoing Pediatric Stomatology Day Surgeries (NA)
- Levobupivacaine and Postoperative Pain Relief (PHASE4)
- Control of Fever in Septic Patients (NA)
- Pharmacokinetics of 3 Formulations of Ibuprofen Suppositories (PHASE1)
- Oral Versus Rectal Ibuprofen for Fever in Young Children - a Randomized Control Study. (PHASE4)
- Ibuprofen Suppositories Administration in Infants and Children (PHASE4)
- Antipyretics for Preventing Recurrences of Febrile Seizures (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ibuprofen suppositories CI brief — competitive landscape report
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- Soroka University Medical Center portfolio CI