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Ibuprofen + Paracetamol
Ibuprofen and paracetamol work synergistically to reduce pain and fever through inhibition of prostaglandin synthesis and central nervous system effects.
Ibuprofen and paracetamol work synergistically to reduce pain and fever through inhibition of prostaglandin synthesis and central nervous system effects. Used for Mild to moderate pain, Fever reduction, Headache.
At a glance
| Generic name | Ibuprofen + Paracetamol |
|---|---|
| Also known as | Ibuprofen, ATC code: M01A E01, Paracetamol (Acetaminophen), ATC code: N02B E01 |
| Sponsor | Ullevaal University Hospital |
| Drug class | Fixed-dose combination of NSAID and analgesic/antipyretic |
| Target | COX-1/COX-2 (ibuprofen); central nervous system analgesic/antipyretic pathways (paracetamol) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin production and providing analgesic, antipyretic, and anti-inflammatory effects. Paracetamol (acetaminophen) primarily acts as a central analgesic and antipyretic agent, with mechanisms involving serotonergic and endocannabinoid pathways. The combination provides enhanced pain relief and fever reduction through complementary mechanisms.
Approved indications
- Mild to moderate pain
- Fever reduction
- Headache
- Musculoskeletal pain
Common side effects
- Gastrointestinal upset
- Nausea
- Dyspepsia
- Hepatotoxicity (paracetamol component)
- Renal impairment (ibuprofen component)
Key clinical trials
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD) (NA)
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis (NA)
- Study of the Contribution of Osteopathic Treatment to Classic Medical Management in Patients With Chronic Low Back Pain (NA)
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
- Selected Exercise Program on Upper Cross Syndrome Post-unilateral Mastectomy (NA)
- Phase 2 Herniorrhaphy Study for Opioid Elimination (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ibuprofen + Paracetamol CI brief — competitive landscape report
- Ibuprofen + Paracetamol updates RSS · CI watch RSS
- Ullevaal University Hospital portfolio CI