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Ibuprofen, Hydrocortisone
Ibuprofen, Hydrocortisone is a NSAID + corticosteroid combination Small molecule drug developed by X-pert Med GmbH. It is currently FDA-approved for Inflammatory pain conditions, Musculoskeletal inflammation.
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, while hydrocortisone suppresses immune and inflammatory responses through glucocorticoid receptor activation.
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, while hydrocortisone suppresses immune and inflammatory responses through glucocorticoid receptor activation. Used for Inflammatory pain conditions, Musculoskeletal inflammation.
At a glance
| Generic name | Ibuprofen, Hydrocortisone |
|---|---|
| Sponsor | X-pert Med GmbH |
| Drug class | NSAID + corticosteroid combination |
| Target | COX-1, COX-2, glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Inflammation, Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2, reducing production of inflammatory mediators including prostaglandins and thromboxanes. Hydrocortisone is a corticosteroid that binds glucocorticoid receptors in the cytoplasm, translocates to the nucleus, and modulates gene expression to suppress inflammatory cytokines, immune cell activation, and tissue inflammation. Together, they provide dual anti-inflammatory and analgesic effects.
Approved indications
- Inflammatory pain conditions
- Musculoskeletal inflammation
Common side effects
- Gastrointestinal irritation
- Dyspepsia
- Headache
- Dizziness
- Corticosteroid-related effects (with prolonged use)
Key clinical trials
- Selected Exercise Program on Upper Cross Syndrome Post-unilateral Mastectomy (NA)
- Effect of a Transversus Abdominis Plane Block on Wound Healing, Stress, and Immune Response After a Cesarean Delivery (NA)
- Guided Bone Regeneration Around Immediate Implants (PHASE4)
- UVB Model Validation Study (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ibuprofen, Hydrocortisone CI brief — competitive landscape report
- Ibuprofen, Hydrocortisone updates RSS · CI watch RSS
- X-pert Med GmbH portfolio CI
Frequently asked questions about Ibuprofen, Hydrocortisone
What is Ibuprofen, Hydrocortisone?
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Related
- Drug class: All NSAID + corticosteroid combination drugs
- Target: All drugs targeting COX-1, COX-2, glucocorticoid receptor
- Manufacturer: X-pert Med GmbH — full pipeline
- Therapeutic area: All drugs in Inflammation, Pain Management
- Indication: Drugs for Inflammatory pain conditions
- Indication: Drugs for Musculoskeletal inflammation
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing