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Ibuprofen group
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever.
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever. Used for Mild to moderate pain, Fever reduction, Inflammatory conditions (e.g., rheumatoid arthritis, osteoarthritis).
At a glance
| Generic name | Ibuprofen group |
|---|---|
| Also known as | Motrin, Brufen® syrup, Samil pharm. Co., Ltd., Active drug, Advil, Brufen |
| Sponsor | University of Salamanca |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | COX-1, COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Inflammation, Fever |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that non-selectively blocks COX-1 and COX-2 enzymes, which catalyze prostaglandin synthesis. By reducing prostaglandin levels, it suppresses inflammatory responses, alleviates pain signaling, and lowers body temperature. This mechanism makes it effective for mild to moderate pain, fever, and inflammatory conditions.
Approved indications
- Mild to moderate pain
- Fever reduction
- Inflammatory conditions (e.g., rheumatoid arthritis, osteoarthritis)
- Dysmenorrhea
Common side effects
- Gastrointestinal upset (nausea, dyspepsia, abdominal pain)
- Headache
- Dizziness
- Rash
- Gastrointestinal bleeding (with chronic use)
- Renal impairment (with chronic use)
Key clinical trials
- Immediate Restoration of a New Implant With High Primary Stability (NA)
- Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis (NA)
- Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement (PHASE2)
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- "Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy" (PHASE4)
- Comparative Assessment of Oral Premedication Regimens in Pediatric Ambulatory Surgery (NA)
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
- Selected Exercise Program on Upper Cross Syndrome Post-unilateral Mastectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ibuprofen group CI brief — competitive landscape report
- Ibuprofen group updates RSS · CI watch RSS
- University of Salamanca portfolio CI