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Ibuprofen and paracetamol
Ibuprofen is a non-selective COX inhibitor, while paracetamol is a weak inhibitor of COX enzymes and also acts on TRPV1 receptors.
Ibuprofen is a non-selective COX inhibitor, while paracetamol is a weak inhibitor of COX enzymes and also acts on TRPV1 receptors. Used for Pain management, Fever reduction, Inflammation.
At a glance
| Generic name | Ibuprofen and paracetamol |
|---|---|
| Sponsor | Universidad Miguel Hernandez de Elche |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) and analgesic |
| Target | COX enzymes and TRPV1 receptors |
| Modality | Small molecule |
| Therapeutic area | Oncology, Pain management, and Gastroenterology |
| Phase | Phase 2 |
Mechanism of action
Ibuprofen and paracetamol are both analgesics and antipyretics that work through different mechanisms. Ibuprofen inhibits the COX enzymes, which are involved in the production of prostaglandins, leading to pain and inflammation. Paracetamol, on the other hand, also inhibits COX enzymes but to a lesser extent, and it also acts on TRPV1 receptors, which are involved in the transmission of pain signals.
Approved indications
- Pain management
- Fever reduction
- Inflammation
Common side effects
- Gastrointestinal upset
- Headache
- Dizziness
Key clinical trials
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis (NA)
- Study of the Contribution of Osteopathic Treatment to Classic Medical Management in Patients With Chronic Low Back Pain (NA)
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
- Selected Exercise Program on Upper Cross Syndrome Post-unilateral Mastectomy (NA)
- Phase 2 Herniorrhaphy Study for Opioid Elimination (PHASE2)
- Helping Osteoarthritis Patients to Walk With NSAID (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ibuprofen and paracetamol CI brief — competitive landscape report
- Ibuprofen and paracetamol updates RSS · CI watch RSS
- Universidad Miguel Hernandez de Elche portfolio CI