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I.V Sedation
I.V. sedation refers to the intravenous administration of sedative and/or hypnotic agents to induce a state of reduced consciousness for medical procedures.
I.V. sedation refers to the intravenous administration of sedative and/or hypnotic agents to induce a state of reduced consciousness for medical procedures. Used for Procedural sedation for diagnostic and therapeutic medical procedures, Anxiolysis and sedation during minor surgical interventions.
At a glance
| Generic name | I.V Sedation |
|---|---|
| Sponsor | Nantes University Hospital |
| Drug class | Sedative/hypnotic agent (class varies by specific agent used) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Sedation |
| Phase | FDA-approved |
Mechanism of action
I.V. sedation typically involves the use of benzodiazepines (e.g., midazolam), opioids (e.g., fentanyl), propofol, or other CNS depressants administered intravenously to suppress consciousness and anxiety during diagnostic or therapeutic procedures. These agents work by enhancing GABAergic inhibition or other CNS pathways, allowing patients to remain responsive to stimuli while experiencing amnesia and analgesia.
Approved indications
- Procedural sedation for diagnostic and therapeutic medical procedures
- Anxiolysis and sedation during minor surgical interventions
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Oversedation
- Nausea and vomiting
Key clinical trials
- Role of Airway Topicalization in Awake Fiberoptic Intubation (PHASE3)
- Using Dexmedetomidine Prior to Intubation in Neonates (PHASE3)
- The Danish Out-of-Hospital Cardiac Arrest Study (PHASE3)
- Fast Acute Sedation at Intensive Care vs. High-dose i.v. Anti-seizure Medication for Treatment of Non-convulsive Status Epilepticus (FAST-trial) (PHASE3)
- Computed Tomography Vs. Endoscopy Study
- Propofol and Dexmedetomidin vs Midazolam Intraoperative Sedation and POCD (NA)
- Intermittent Boluses Versus Infusion of Propofol During Gastroscopy (NA)
- Dose Systemic Lidocaine Improve the Quality of Recovery After Colorectal Endoscopic Submucosal Dissection (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- I.V Sedation CI brief — competitive landscape report
- I.V Sedation updates RSS · CI watch RSS
- Nantes University Hospital portfolio CI