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i.v. mannitol

University Hospital, Saarland · FDA-approved active Small molecule

Mannitol is an osmotic diuretic that draws fluid from tissues into the intravascular space and increases urine output to reduce intracranial and intraocular pressure.

Mannitol is an osmotic diuretic that draws fluid from tissues into the intravascular space and increases urine output to reduce intracranial and intraocular pressure. Used for Cerebral edema and elevated intracranial pressure, Acute glaucoma and elevated intraocular pressure, Oliguria and acute kidney injury (renal protective agent).

At a glance

Generic namei.v. mannitol
SponsorUniversity Hospital, Saarland
Drug classOsmotic diuretic
ModalitySmall molecule
Therapeutic areaNeurology, Ophthalmology
PhaseFDA-approved

Mechanism of action

Mannitol is a sugar alcohol that creates an osmotic gradient, pulling water from the extravascular and intracellular compartments into the blood vessels and then into the urine. This reduces cerebral edema and intracranial pressure by decreasing brain water content, and similarly reduces intraocular pressure. It is administered intravenously and acts rapidly to promote diuresis while maintaining or expanding plasma volume.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results