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Hypotonic fluid
Hypotonic fluid reduces serum osmolality by providing free water, promoting water movement into cells and reducing extracellular fluid volume.
Hypotonic fluid reduces serum osmolality by providing free water, promoting water movement into cells and reducing extracellular fluid volume. Used for Hypernatremia management, Hyperosmolar dehydration, Cellular dehydration.
At a glance
| Generic name | Hypotonic fluid |
|---|---|
| Also known as | Hypotonic fluid,, 0.2 % saline in 5 % dextrose, 0.2 % saline in 5% dextrose |
| Sponsor | All India Institute of Medical Sciences |
| Drug class | Intravenous fluid therapy / Electrolyte solution |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Fluid and Electrolyte Management |
| Phase | Phase 3 |
Mechanism of action
Hypotonic solutions (such as 0.45% saline or 5% dextrose in water) have a lower osmotic pressure than plasma, causing water to shift from the extracellular space into cells. This mechanism is used clinically to treat hypernatremia and hyperosmolar states by restoring cellular hydration and normalizing serum osmolality.
Approved indications
- Hypernatremia management
- Hyperosmolar dehydration
- Cellular dehydration
Common side effects
- Hyponatremia (if administered too rapidly)
- Cerebral edema (in severe cases of overcorrection)
- Phlebitis at infusion site
Key clinical trials
- CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS (PHASE4)
- Severe Impairment of Solute-Free Water Clearance in Patients With HIV Infection
- Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment (PHASE4)
- Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia (PHASE3)
- Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery (NA)
- Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery (NA)
- Comparison of the Isotonic and Hypotonic Intravenous Maintenance Fluids In Term Newborns: Neofluid Study
- Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock (SHOCK) Trial (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Hypotonic fluid CI brief — competitive landscape report
- Hypotonic fluid updates RSS · CI watch RSS
- All India Institute of Medical Sciences portfolio CI