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Hypertonic lactate
Hypertonic lactate provides osmotic support and metabolic substrate to restore cellular energy and reduce intracranial pressure in critically ill patients.
Hypertonic lactate provides osmotic support and metabolic substrate to restore cellular energy and reduce intracranial pressure in critically ill patients. Used for Hypovolemic shock and hemorrhagic shock, Traumatic brain injury with elevated intracranial pressure, Septic shock with tissue hypoperfusion.
At a glance
| Generic name | Hypertonic lactate |
|---|---|
| Also known as | Totilac, Totilac™ |
| Sponsor | Innogene Kalbiotech Pte. Ltd |
| Drug class | Hypertonic solution / Metabolic support agent |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Intensive Care Medicine |
| Phase | FDA-approved |
Mechanism of action
Hypertonic lactate acts as both an osmotic agent and a readily metabolizable fuel source. It helps restore intracellular ATP production, reduce cerebral edema, and improve microcirculatory perfusion in conditions of shock or severe tissue hypoxia. The lactate is oxidized by mitochondria to generate energy while the hypertonic solution draws fluid from the interstitial space, reducing intracranial pressure.
Approved indications
- Resuscitation in hemorrhagic shock and trauma
- Cerebral edema and elevated intracranial pressure
- Septic shock and severe metabolic acidosis
Common side effects
- Hyperchloremic acidosis
- Hypernatremia
- Phlebitis at infusion site
- Rebound intracranial hypertension
Key clinical trials
- Hypertonic Lactate After Cardiac Arrest (PHASE2)
- Effect of Fluid Resuscitation on Lactate in Traumatic Injury Patients (PHASE1, PHASE2)
- Sodium Lactate Versus Hypertonic Saline Solution in the Treatment of Intracranial Hypertensive Episodes in Severe Brain Injured Patients (PHASE3)
- Sodium Lactate and Brain Relaxation (LSD) (PHASE3)
- RL Versus Glucose Saline in Cancer Patient Undergoing Major Surgeries and Its Impact on Electrolytes, GLC & pH (NA)
- Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury (NA)
- Comparison of the Effects of an Hypertonic Solution With Ringer Lactate on Right Ventricular Function Following Cardiac Surgery (PHASE3)
- The Use of a Restrictive Fluid Regimen With Hypertonic Saline for Patients Undergoing Pancreaticoduodenectomy (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |