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Hyperbaric oxygen treatment
Hyperbaric oxygen treatment increases the partial pressure of oxygen in blood and tissues by delivering 100% oxygen at pressures greater than atmospheric, enhancing oxygen delivery to hypoxic tissues.
Hyperbaric oxygen treatment increases the partial pressure of oxygen in blood and tissues by delivering 100% oxygen at pressures greater than atmospheric, enhancing oxygen delivery to hypoxic tissues. Used for Diabetic foot ulcers, Chronic wounds and non-healing wounds, Carbon monoxide poisoning.
At a glance
| Generic name | Hyperbaric oxygen treatment |
|---|---|
| Sponsor | Restorix Research Institute, LLLP |
| Modality | Small molecule |
| Therapeutic area | Wound Care, Hypoxic Tissue Disorders |
| Phase | FDA-approved |
Mechanism of action
The therapy involves breathing pure oxygen in a pressurized chamber, which increases dissolved oxygen in plasma and enhances oxygen diffusion into tissues. This promotes angiogenesis, reduces edema, enhances immune function, and stimulates fibroblast activity to accelerate wound healing and tissue repair in hypoxic or ischemic conditions.
Approved indications
- Diabetic foot ulcers
- Chronic wounds and non-healing wounds
- Carbon monoxide poisoning
- Decompression sickness (the bends)
- Radiation tissue injury
- Osteomyelitis
Common side effects
- Barotrauma (ear/sinus pressure injury)
- Myopia (temporary vision changes)
- Oxygen toxicity (seizures, rare)
- Claustrophobia/anxiety
- Fatigue
Key clinical trials
- Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study (PHASE4)
- Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions
- Adjunctive Hyperbaric Oxygen Treatment for Patients With Necrotizing Soft-Tissue Infection (HOT-NSTI Trial). Investigator-initiated, International, Multicentre, Superiority, Randomized, Open-label, Clinical Trial. (PHASE4)
- Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder - a Pragmatic, Double Blinded Randomized Trial (NA)
- Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments (NA)
- Optimal Number of Hyperbaric Oxygen Treatments for Carbon Monoxide Poisoning (NA)
- Self-hangIng Patient and Hyperbaric Oxygen Therapy _ SIPHON Study (PHASE4)
- Hyperbaric Oxygen Therapy in Complex Regional Pain Syndrome (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |