Last reviewed 2026-04-23 · How we verify

Hydroxychloroquine with Azithromycin

Hydroxychloroquine is a chloroquine derivative that inhibits heme polymerase, while Azithromycin is a macrolide antibiotic that inhibits protein synthesis.

Hydroxychloroquine is a chloroquine derivative that inhibits heme polymerase, while Azithromycin is a macrolide antibiotic that inhibits protein synthesis. Used for Malaria, Lupus, Rheumatoid Arthritis.

At a glance

Mechanism of action

Hydroxychloroquine has been shown to have immunomodulatory effects, while Azithromycin has been used to treat various bacterial infections.

Approved indications

• Malaria
• Lupus
• Rheumatoid Arthritis
• COVID-19

Common side effects

• Nausea
• Diarrhea
• Abdominal pain
• Vomiting
• Headache
• Dizziness
• Fatigue
• Insomnia
• Allergic reactions
• Cardiac arrhythmias

Key clinical trials

• Immunomodulatory Treatment of Interstitial Lung Disease Associated With Surfactant Related Gene Variants (PHASE2)
• Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment (PHASE3)
• Safety and Efficacy of Intravenous Wharton's Jelly Derived Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Due to COVID 19 (PHASE1, PHASE2)
• Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (PHASE3)
• Hydroxychloroquine,Hydroxychloroquine,Azithromycin in the Treatment of SARS CoV-2 Infection (PHASE3)
• A Study of Quintuple Therapy to Treat COVID-19 Infection (PHASE2)
• Randomised Evaluation of COVID-19 Therapy (PHASE3)
• Non-comparative Trial of the Combination of HCQ and AZI in the Treatment of ICU Patients (PHASE2)

Primary sources

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