Last reviewed · How we verify
hydrochlorothiazide tablets
At a glance
| Generic name | hydrochlorothiazide tablets |
|---|---|
| Sponsor | Daiichi Sankyo |
| Drug class | Thiazide Diuretic [EPC] |
| Modality | Small molecule |
| Phase | FDA-approved |
Approved indications
Boxed warnings
- WARNING: FETAL TOXICITY When pregnancy is detected, discontinue lisinopril and hydrochlorothiazide tablets as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See Warnings, Fetal Toxicity .
Common side effects
- Dizziness
- Headache
- Cough
- Fatigue
- Orthostatic Effects
- Diarrhea
- Nausea
- Upper Respiratory Infection
- Muscle Cramps
- Asthenia
- Paresthesia
- Hypotension
Serious adverse events
- Angioedema
- Angioedema with laryngeal edema
- Intestinal angioedema
- Syncope
- Orthostatic hypotension
Key clinical trials
- Triple Antihypertensive Medication After Intracerebral Hemorrhage for Blood Pressure Control (NA)
- Efficacy and Safety of Olmesartan Associated With Chlorthalidone Versus Benicar HCT® in Essential Hypertension Control (PHASE3)
- Efficacy and Safety of Olmesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control (PHASE3)
- Study to Evaluate the Influence of Hydrochlorothiazide on Dermal Photosensitivity and DNA Stability - a Pilot Study (HCTox Study) (PHASE1)
- Sympathetic Regulation of Large Artery Stiffness in Humans With ISH (EARLY_PHASE1)
- Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hypertension (PHASE3)
- The Role of Skin Sodium Accumulation in Chronic Kidney Disease (NA)
- Efficacy and Safety of a Single-pill Fixed Combination of Sufficient Losartan/Hydrochlorothiazide in Chinese Hypertensive Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |