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hyaluronic Acid + platelet-rich plasma
Hyaluronic acid and platelet-rich plasma work synergistically to promote tissue regeneration and reduce inflammation through growth factor delivery and extracellular matrix support.
Hyaluronic acid and platelet-rich plasma work synergistically to promote tissue regeneration and reduce inflammation through growth factor delivery and extracellular matrix support. Used for Osteoarthritis (joint cartilage degeneration), Soft tissue injuries and wound healing.
At a glance
| Generic name | hyaluronic Acid + platelet-rich plasma |
|---|---|
| Also known as | Cellular Matrix/A-CP HA Kit |
| Sponsor | University of Milan |
| Drug class | Regenerative medicine / Biologic combination |
| Modality | Small molecule |
| Therapeutic area | Orthopedics / Regenerative Medicine |
| Phase | FDA-approved |
Mechanism of action
Hyaluronic acid serves as a biocompatible scaffold that retains moisture and facilitates cell migration and proliferation. Platelet-rich plasma delivers concentrated growth factors (PDGF, VEGF, FGF, TGF-β) that stimulate tissue repair, angiogenesis, and collagen synthesis. Together, they create an optimal microenvironment for regenerative healing in damaged tissues.
Approved indications
- Osteoarthritis (joint cartilage degeneration)
- Soft tissue injuries and wound healing
Common side effects
- Injection site pain or swelling
- Temporary inflammation
- Infection risk (minimal with sterile preparation)
Key clinical trials
- Efficacy of Therapy With PRP Injections Versus HA in Patients With Advanced Grade of GONArthrosis (NA)
- IDENTIFICATION OF BIOMARKERS ASSOCIATED WITH THE SEVERITY AND RADIO-CLINICAL PROGRESSION OF KNEE OSTEOARTHRITIS
- Combination of PRP and XLHA Prepared With RegenMatrix Medical Device To Treat Moderate to Severe Knee Osteoarthritis (NA)
- Effect of PRP vs Corticosteroid in Rotator Cuff Tendinopathy Subtypes in Arthroscopic Repair (PHASE4)
- Combined Use of PRP and Hyaluronic Acid for Infiltrative Treatment of Patients With Knee Osteoarthritis (NA)
- PRP Versus HA IN OSTEOARTHRITIS OF THE PATELLOFEMORAL JOINT (NA)
- Microneedling vs Dermabrasion for Early Facial Scar Resurfacing (NA)
- Evaluation of Treatment of Osteoarthritis of the Knee in the Form of Chondromalacia of the Articular Cartilage Treated in the Arthroscopic Technique With the Use of:Autogenous Transplantation of Fragmented Adipose Tissue,PRP GF,Mesenchymal Cells,Hyaluronic Acid-low Molecular Weight and Cross-linked (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- hyaluronic Acid + platelet-rich plasma CI brief — competitive landscape report
- hyaluronic Acid + platelet-rich plasma updates RSS · CI watch RSS
- University of Milan portfolio CI