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HS-20089
HS-20089 is a selective inhibitor of fibroblast growth factor receptor (FGFR) that blocks aberrant FGFR signaling in cancer cells.
HS-20089 is a selective inhibitor of fibroblast growth factor receptor (FGFR) that blocks aberrant FGFR signaling in cancer cells. Used for FGFR-altered solid tumors (Phase 3 development).
At a glance
| Generic name | HS-20089 |
|---|---|
| Sponsor | Hansoh BioMedical R&D Company |
| Drug class | FGFR inhibitor |
| Target | FGFR (Fibroblast Growth Factor Receptor) |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
HS-20089 targets FGFR kinase activity to inhibit downstream proliferation and survival pathways in tumors with FGFR alterations. By selectively blocking FGFR signaling, the drug aims to suppress tumor growth in cancers driven by FGFR mutations, fusions, or amplifications.
Approved indications
- FGFR-altered solid tumors (Phase 3 development)
Common side effects
- Hyperphosphatemia
- Diarrhea
- Fatigue
- Nausea
Key clinical trials
- HS-20089 for Injection in Patients With Platinum-Resistant Recurrent Epithelial Ovarian Cancer (PHASE3)
- HS-10502 Combination Treatment in Patients With Advanced Solid Tumors (PHASE1)
- HS-20089 in Patients With Ovarian Cancer and Endometrial Cancer (PHASE2)
- HS-20089 Combination Treatment in Subjects With Advanced Solid Tumors (PHASE1)
- A Study of HS-20089 in Patients With Advanced Solid Tumors (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- HS-20089 CI brief — competitive landscape report
- HS-20089 updates RSS · CI watch RSS
- Hansoh BioMedical R&D Company portfolio CI