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high level Vitamin D
High level Vitamin D works by regulating calcium and phosphate metabolism in the body.
High level Vitamin D works by regulating calcium and phosphate metabolism in the body. Used for Prevention of falls in older adults with vitamin D deficiency, Treatment of rickets and osteomalacia.
At a glance
| Generic name | high level Vitamin D |
|---|---|
| Also known as | Dibase |
| Sponsor | National Cancer Institute, Naples |
| Drug class | Vitamin D analog |
| Target | Vitamin D receptor |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
High level Vitamin D achieves this by binding to the Vitamin D receptor, which influences the expression of genes involved in calcium and phosphate homeostasis. This ultimately leads to increased absorption of calcium and phosphate from the gut, and reduced excretion of these minerals in the urine.
Approved indications
- Prevention of falls in older adults with vitamin D deficiency
- Treatment of rickets and osteomalacia
Common side effects
- Hypercalcemia
- Nausea
- Headache
Key clinical trials
- Toddler Biomarker of Nutrition Study (NA)
- Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma (PHASE3)
- Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older
- Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment (NA)
- Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia (PHASE2)
- Protein Supplement and Exercise Training for the Treatment of Sarcopenia Risk in Older Adults (NA)
- Structured Review: To Optimise Management and Prevent Harm in COPD (NA)
- Omega-3 Supplementation and Mental Health in College Students (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |