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Hexavalent vaccine
Hexavalent vaccine is a vaccine Biologic drug developed by International Centre for Diarrhoeal Disease Research, Bangladesh. It is currently FDA-approved for Prevention of diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b infection in infants and children. Also known as: Diphtheria, tetanus, pertussis, hepatitis B,, poliomyelitis and Haemophilus influenzae type b conjugate vaccine (adsorbed)., HEXASIIL.
A hexavalent vaccine that provides immunization against six infectious diseases by stimulating the immune system to produce antibodies and cellular immunity against multiple pathogens.
A hexavalent vaccine that provides immunization against six infectious diseases by stimulating the immune system to produce antibodies and cellular immunity against multiple pathogens. Used for Prevention of diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b infection in infants and children.
At a glance
| Generic name | Hexavalent vaccine |
|---|---|
| Also known as | Diphtheria, tetanus, pertussis, hepatitis B,, poliomyelitis and Haemophilus influenzae type b conjugate vaccine (adsorbed)., HEXASIIL |
| Sponsor | International Centre for Diarrhoeal Disease Research, Bangladesh |
| Drug class | vaccine |
| Modality | Biologic |
| Therapeutic area | Immunology |
| Phase | FDA-approved |
Mechanism of action
Hexavalent vaccines typically combine immunogens against diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b. The vaccine works by presenting inactivated or attenuated antigens that trigger both humoral (antibody) and cell-mediated immune responses, conferring protection against these six diseases with a single injection. This combination approach improves vaccination compliance and reduces the number of injections needed in pediatric immunization schedules.
Approved indications
- Prevention of diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b infection in infants and children
Common side effects
- Injection site pain, redness, or swelling
- Fever
- Irritability or fussiness
- Drowsiness
- Loss of appetite
Key clinical trials
- The Oral Hexavalent Reassortant Rotavirus Attenuated Live Vaccine (Vero Cells) (PHASE1)
- Evaluating the Dose, Safety, Tolerability, and Immunogenicity of Mosaic Hexavalent Influenza Vaccine VRCFLUMOS0116-00-VP (FluMos-v2) With and Without ALFQ Adjuvant in Healthy Adults (PHASE1)
- Maternal Determinants of Infant Immunity to Pertussis (PHASE4)
- Trial to Evaluate the Safety, Tolerability, and Immunogenicity of a Mosaic Hexavalent Influenza Vaccine VRC-FLUMOS0116-00-VP (FluMos-v2) in Healthy Adults (PHASE1)
- Phase I/II Study to a Assess the GBS-06 Vaccine Manufactured by Inventprise, Inc., in Healthy, Non-Pregnant, Adult Women of Childbearing Age. (PHASE1, PHASE2)
- Study of DTwP-HepB-Hib-IPV (SHAN6™) Vaccine Administered Concomitantly With Routine Pediatric Vaccines to Healthy Infants and Toddlers in Thailand (PHASE3)
- PhaseⅡClinical Trial of Oral Hexavalent Reassortant Rotavirus Attenuated Live Vaccine (Vero Cells) (PHASE2)
- Infant Malaria Vaccine Schedule Optimization (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Hexavalent vaccine CI brief — competitive landscape report
- Hexavalent vaccine updates RSS · CI watch RSS
- International Centre for Diarrhoeal Disease Research, Bangladesh portfolio CI
Frequently asked questions about Hexavalent vaccine
What is Hexavalent vaccine?
How does Hexavalent vaccine work?
What is Hexavalent vaccine used for?
Who makes Hexavalent vaccine?
Is Hexavalent vaccine also known as anything else?
What drug class is Hexavalent vaccine in?
What development phase is Hexavalent vaccine in?
What are the side effects of Hexavalent vaccine?
Related
- Drug class: All vaccine drugs
- Manufacturer: International Centre for Diarrhoeal Disease Research, Bangladesh — full pipeline
- Therapeutic area: All drugs in Immunology
- Indication: Drugs for Prevention of diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b infection in infants and children
- Also known as: Diphtheria, tetanus, pertussis, hepatitis B,, poliomyelitis and Haemophilus influenzae type b conjugate vaccine (adsorbed)., HEXASIIL
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing