Last reviewed · How we verify
HETASTARCH
At a glance
| Generic name | HETASTARCH |
|---|---|
| Drug class | Plasma Volume Expander [EPC] |
| Phase | FDA-approved |
Approved indications
Boxed warnings
- BOXED WARNING BOXED WARNING
Common side effects
- Rash
- Urticaria
- Pruritus
- Flushing
- Fever
- Chills
- Headaches
- Muscle pains
- Vomiting
- Coughing
- Sneezing
- Restlessness
Serious adverse events
- Increased mortality in critically ill subjects with sepsis
- Acute kidney injury (AKI) requiring renal replacement therapy
- Death
- Anaphylactic/anaphylactoid reactions
- Cardiac arrest
- Ventricular fibrillation
- Severe hypotension
- Non-cardiac pulmonary edema
- Disseminated intravascular coagulopathy
- Intracranial bleeding
Key clinical trials
- Comparing Reduction With ESD- Versus APC-TORe (NA)
- Re-bleeding in Giant Meningioma and Intraoperative Hydroxyethyl Starch (HES) Fluid Therapy
- Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications (PHASE4)
- Crystalloid vs Colloid for Hemodynamics During Anesthesia Induction in TAVR Patients (NA)
- Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection (NA)
- Cardiac Output in Preeclamptic (NA)
- Optimizing Fluid Resuscitation in Adults With Major Burns: A Randomized Trial of Burn Navigator™ Versus Parkland Formula (PHASE4)
- Priming of Cardiopulmonary Bypass With Hydroxyethyl Starch 130/0.4 or Sodium Chloride 0.9% : Pilot Study in Adult Elective Conventional Cardiac Surgery (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |