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Halometasone Triclosan
Halometasone is a topical corticosteroid that reduces inflammation, while triclosan is an antimicrobial agent that inhibits bacterial growth, together providing anti-inflammatory and antimicrobial effects.
Halometasone is a topical corticosteroid that reduces inflammation, while triclosan is an antimicrobial agent that inhibits bacterial growth, together providing anti-inflammatory and antimicrobial effects. Used for Inflammatory skin conditions with antimicrobial coverage (e.g., infected eczema, dermatitis).
At a glance
| Generic name | Halometasone Triclosan |
|---|---|
| Also known as | regular moisturizer, wet wrap bandage |
| Sponsor | Beijing Friendship Hospital |
| Drug class | Topical corticosteroid with antimicrobial agent |
| Target | Glucocorticoid receptor (halometasone); bacterial enoyl-ACP reductase (triclosan) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Halometasone works by binding to glucocorticoid receptors and suppressing inflammatory cytokine production and immune cell activation in the skin. Triclosan acts as a broad-spectrum antimicrobial by inhibiting bacterial lipid synthesis and cell membrane integrity. This combination is used in topical formulations to treat inflammatory skin conditions with secondary bacterial colonization or infection risk.
Approved indications
- Inflammatory skin conditions with antimicrobial coverage (e.g., infected eczema, dermatitis)
Common side effects
- Local skin irritation
- Skin atrophy (with prolonged use)
- Contact dermatitis
Key clinical trials
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |