Last reviewed · How we verify
Haldol
At a glance
| Generic name | Haldol |
|---|---|
| Also known as | haloperidol |
| Sponsor | Michelle Weckmann |
| Modality | Small molecule |
| Therapeutic area | Other |
| Phase | FDA-approved |
Approved indications
Boxed warnings
- WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. HALDOL DECANOATE is not approved for the treatment of patients with dementia-related psychosis [see Warnings and Precautions (5.1) ] . WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS See full prescribing information for complete boxed warning. Elderly patients with dem
Common side effects
- Parkinsonism
- Oculogyric crisis
- Sedation
- Somnolence
- Dyskinesia
- Dystonia
- Cogwheel rigidity
- Muscle rigidity
- Constipation
- Dry mouth
- Weight increased
- Hyperprolactinemia
Serious adverse events
- Neuroleptic malignant syndrome
- Tardive dyskinesia
- Sudden death
- Torsades de pointes
- QTc interval prolongation
- Seizures
- Leukopenia
- Neutropenia
- Agranulocytosis
- Hypersensitivity reactions
Key clinical trials
- Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer (PHASE2, PHASE3)
- Haloperidol and Lorazepam for Delirium in Patients With Advanced Cancer (PHASE2)
- Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care (PHASE2, PHASE3)
- Comparing Haloperidol to Olanzapine in the Treatment of Suspected Cannabinoid Hyperemesis in the Emergency Department (PHASE3)
- Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy (PHASE2, PHASE3)
- Maternal And Infant Antipsychotic Study
- Do Antipsychotics Block Insulin Action in the Brain: is it a Class Effect? (PHASE4)
- Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the ED: A RCT (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |