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HAIC of FOLFOX
HAIC of FOLFOX is a Chemotherapy combination (regional delivery) Small molecule drug developed by Tianjin Medical University Cancer Institute and Hospital. It is currently FDA-approved for Hepatocellular carcinoma, Advanced liver cancer. Also known as: Oxaliplatin , fluorouracil, and leucovorin, FOLFOX.
HAIC (hepatic arterial infusion chemotherapy) of FOLFOX delivers chemotherapy directly into the hepatic artery to treat liver cancers with high local drug concentration.
HAIC (hepatic arterial infusion chemotherapy) of FOLFOX delivers chemotherapy directly into the hepatic artery to treat liver cancers with high local drug concentration. Used for Hepatocellular carcinoma, Advanced liver cancer.
At a glance
| Generic name | HAIC of FOLFOX |
|---|---|
| Also known as | Oxaliplatin , fluorouracil, and leucovorin, FOLFOX |
| Sponsor | Tianjin Medical University Cancer Institute and Hospital |
| Drug class | Chemotherapy combination (regional delivery) |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
Mechanism of action
HAIC is an interventional oncology technique that infuses chemotherapy agents directly into the hepatic artery supplying the tumor, maximizing local drug exposure while minimizing systemic toxicity. FOLFOX is a combination regimen of 5-fluorouracil, leucovorin, and oxaliplatin that inhibits DNA synthesis and repair. This combination approach leverages regional delivery to enhance efficacy in hepatocellular carcinoma and other liver malignancies.
Approved indications
- Hepatocellular carcinoma
- Advanced liver cancer
Common side effects
- Neutropenia
- Thrombocytopenia
- Nausea and vomiting
- Diarrhea
- Peripheral neuropathy
- Hepatotoxicity
Key clinical trials
- HAIC Plus Systemic Therapy as De-escalation Therapy Strategy for Biliary Tract Cancer (NA)
- Conversion Therapy With FOLFOX-HAIC Plus Lenvatinib And Tislelizumab For Hepatocellular Carcinoma With Vp3 Portal Vein Tumor Thrombus (PHASE2)
- Hepatic Artery Infusion Chemotherapy (HAIC) Plus Durvalumab for Advanced Hepatocellular Carcinoma (PHASE2)
- Toripalimab Plus Bevacizumab Combined Three Intra-arterial Therapies (TACE, HAIC, or TACE-HAIC) for Unresectable Hepatocellular Carcinoma: a Phase 2, Multicenter Randomised Non-comparative Trial (PHASE2)
- HAIC in Combination With PD-1 Inhibitors and Lenvatinib for High Tumor Burden Advanced HCC (CHANCE2416)
- Camrelizumab, Apatinib Plus HAIC Versus Camrelizumab and Apatinib for HCC With Portal Vein Invasion: a Randomized Trial (PHASE3)
- A Platform Trial for Personalized and Adaptive Therapies in Hepatocellular Carcinoma (PHASE2)
- FOLFOX-HAIC Combined With Donafenib and Pucotenlimab as First-Line Treatment for Unresectable Intrahepatic Cholangiocarcinoma (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- HAIC of FOLFOX CI brief — competitive landscape report
- HAIC of FOLFOX updates RSS · CI watch RSS
- Tianjin Medical University Cancer Institute and Hospital portfolio CI
Frequently asked questions about HAIC of FOLFOX
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Related
- Drug class: All Chemotherapy combination (regional delivery) drugs
- Manufacturer: Tianjin Medical University Cancer Institute and Hospital — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Hepatocellular carcinoma
- Indication: Drugs for Advanced liver cancer
- Also known as: Oxaliplatin , fluorouracil, and leucovorin, FOLFOX
- Compare: HAIC of FOLFOX vs similar drugs
- Pricing: HAIC of FOLFOX cost, discount & access