Last reviewed 2026-04-23 · How we verify

Gymiso®

Gymiso is a mifepristone-based medication that acts as a progesterone receptor antagonist to induce medical abortion.

Gymiso is a mifepristone-based medication that acts as a progesterone receptor antagonist to induce medical abortion. Used for Medical abortion (pregnancy termination up to a specified gestational age).

At a glance

Mechanism of action

Mifepristone competitively blocks progesterone receptors in the uterus, preventing the hormone from maintaining pregnancy. This leads to detachment of the endometrium and cessation of pregnancy support. It is typically used in combination with a prostaglandin analog (such as misoprostol) to complete the abortion process.

Approved indications

• Medical abortion (pregnancy termination up to a specified gestational age)

Common side effects

• Vaginal bleeding
• Abdominal pain/cramping
• Nausea
• Diarrhea
• Headache

Key clinical trials

• Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination (PHASE3)

Primary sources

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