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guideline-recommended SoC
This drug works by inhibiting the PD-1 receptor, which plays a key role in the immune system's ability to recognize and attack cancer cells.
This drug works by inhibiting the PD-1 receptor, which plays a key role in the immune system's ability to recognize and attack cancer cells. Used for Non-small cell lung cancer, PD-L1 positive, Head and neck squamous cell carcinoma, Melanoma.
At a glance
| Generic name | guideline-recommended SoC |
|---|---|
| Sponsor | Shanghai East Hospital |
| Drug class | PD-1 inhibitor |
| Target | PD-1 |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
By blocking the PD-1 receptor, the drug allows the immune system to recognize and attack cancer cells more effectively, leading to a reduction in tumor growth and spread. This mechanism is thought to be responsible for the drug's anti-tumor effects. The drug's ability to inhibit the PD-1 receptor also leads to a reduction in inflammation and an increase in the production of anti-tumor immune cells.
Approved indications
- Non-small cell lung cancer, PD-L1 positive
- Head and neck squamous cell carcinoma
- Melanoma
- Kidney cancer
- Class III-IV heart failure
Common side effects
- Pneumonitis
- Hypothyroidism
- Diarrhea
- Fatigue
- Nausea
Key clinical trials
- A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation (PHASE2)
- Implementation of a Combination Intervention for Sustainable Blood Pressure Control (NA)
- Using a Personalized Decision Support Tool to Help People With Type 1 Diabetes Manage Exercise (NA)
- A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED) (PHASE2)
- The PROTECT (PrEP Optimization Through Telehealth Care and Treatment) Trial (NA)
- Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV (NA)
- Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock (PHASE4)
- Study of Safety/Feasibility of a Hybrid Model of Tertiary and Community Delivery of Hepatic Artery Infusion Chemotherapy (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- guideline-recommended SoC CI brief — competitive landscape report
- guideline-recommended SoC updates RSS · CI watch RSS
- Shanghai East Hospital portfolio CI