Last reviewed · How we verify
Guaifenesin Syrup
Guaifenesin reduces mucus viscosity and promotes clearance of respiratory secretions by increasing hydration of mucus in the airways.
Guaifenesin reduces mucus viscosity and promotes clearance of respiratory secretions by increasing hydration of mucus in the airways. Used for Productive cough associated with common cold, bronchitis, and other respiratory conditions.
At a glance
| Generic name | Guaifenesin Syrup |
|---|---|
| Also known as | Guaifenesin, Methylephedrine and Chlorphenamine Syrup |
| Sponsor | Liaoning University of Traditional Chinese Medicine |
| Drug class | Expectorant |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | FDA-approved |
Mechanism of action
Guaifenesin is an expectorant that works by thinning mucus and making it easier to expectorate. It increases the water content of respiratory secretions, reducing their viscosity and allowing for more effective clearance through coughing. This mechanism helps relieve congestion associated with colds, flu, and other respiratory conditions.
Approved indications
- Productive cough associated with common cold, bronchitis, and other respiratory conditions
Common side effects
- Nausea
- Vomiting
- Dizziness
- Headache
- Rash
Key clinical trials
- A Clinical Evidence Study Evaluating Quality of Life Parameters Following Treatment With Robitussin (PHASE4)
- Bioequivalence Study Comparing Mucinex Extended-release 600 mg Tablets to Immediate-release Guaifenesin 600 mg in Healthy Volunteers (PHASE1)
- Comparison Between Oxomemazine, Guaifenesin and Potassium Iodate Versus Guaifenesin Monotherapy in Acute Cough Treatment (PHASE3)
- Study to Characterize the Pharmacokinetics of 3 Marketed Products Containing 200 mg Guaifenesin in Healthy Volunteers. (PHASE1)
- Transpulmin Suppository and Guaiacol Compared to Transpulmin Syrup in Pediatric Participants With Productive Cough (PHASE3)
- Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo (PHASE4)
- Comparison of Efficacy and Tolerability of Two Cough Syrups in Cough Due to Cold in Children. (PHASE4)
- Effectiveness Study of Integrative Treatment for Pediatric Pneumonia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Guaifenesin Syrup CI brief — competitive landscape report
- Guaifenesin Syrup updates RSS · CI watch RSS
- Liaoning University of Traditional Chinese Medicine portfolio CI