Last reviewed · How we verify
GSK Biologicals' DTPa-IPV/Hib vaccine
GSK Biologicals' DTPa-IPV/Hib vaccine is a Inactivated combination vaccine Biologic drug developed by GlaxoSmithKline. It is currently in Phase 3 development for Primary immunization against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b in infants and children.
This combination vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b.
This combination vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b. Used for Primary immunization against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b in infants and children.
At a glance
| Generic name | GSK Biologicals' DTPa-IPV/Hib vaccine |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Inactivated combination vaccine |
| Modality | Biologic |
| Therapeutic area | Immunology / Infectious Disease Prevention |
| Phase | Phase 3 |
Mechanism of action
DTPa-IPV/Hib is a pentavalent inactivated vaccine containing antigens from five pathogens. The diphtheria and tetanus components are toxoids (inactivated toxins), the acellular pertussis component contains purified bacterial antigens, the IPV component contains inactivated poliovirus strains, and the Hib component contains conjugated polysaccharide. Together, these antigens trigger both humoral and cell-mediated immune responses to provide protection against these infectious diseases.
Approved indications
- Primary immunization against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b in infants and children
Common side effects
- Injection site reactions (pain, redness, swelling)
- Fever
- Irritability
- Drowsiness
- Loss of appetite
Key clinical trials
- Safety and Immunogenicity of GSK Meningococcal Group B Vaccine and 13-valent Pneumococcal Vaccine Administered Concomitantly With Routine Infant Vaccines to Healthy Infants (PHASE3)
- Restoration of Immunity to Vaccine Preventable Diseases After CART-T Cell Therapy
- Immunogenicity and Safety of Meningococcal Vaccine GSK 134612 Co-administered With Pneumococcal and DTPa-HBV-IPV/Hib Vaccines (PHASE3)
- Safety and Immunogenicity of a Booster Dose of New Formulations of GlaxoSmithKline Biologicals' DTPa-HBV-IPV/Hib Vaccine (GSK217744) (PHASE2)
- Immunogenicity and Safety Study of GlaxoSmithKline Biologicals' GSK2202083A Vaccine Administered as a Booster Dose (PHASE2)
- Safety of GSK Biologicals' Infanrix-IPV+HibTM Vaccine in Healthy Vietnamese Toddlers (PHASE3)
- Pneumococcal Vaccine Booster Study in Healthy Children 11-18 Months Old Previously Primed With the Same Vaccines (PHASE3)
- Assess the Safety & Reactogenicity of DTPa-IPV/Hib Vaccine Administered at 3, 4, 5 & 18 Mths of Age, in Healthy Infants (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- GSK Biologicals' DTPa-IPV/Hib vaccine CI brief — competitive landscape report
- GSK Biologicals' DTPa-IPV/Hib vaccine updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI
Frequently asked questions about GSK Biologicals' DTPa-IPV/Hib vaccine
What is GSK Biologicals' DTPa-IPV/Hib vaccine?
How does GSK Biologicals' DTPa-IPV/Hib vaccine work?
What is GSK Biologicals' DTPa-IPV/Hib vaccine used for?
Who makes GSK Biologicals' DTPa-IPV/Hib vaccine?
What drug class is GSK Biologicals' DTPa-IPV/Hib vaccine in?
What development phase is GSK Biologicals' DTPa-IPV/Hib vaccine in?
What are the side effects of GSK Biologicals' DTPa-IPV/Hib vaccine?
Related
- Drug class: All Inactivated combination vaccine drugs
- Manufacturer: GlaxoSmithKline — full pipeline
- Therapeutic area: All drugs in Immunology / Infectious Disease Prevention
- Indication: Drugs for Primary immunization against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b in infants and children
- Compare: GSK Biologicals' DTPa-IPV/Hib vaccine vs similar drugs
- Pricing: GSK Biologicals' DTPa-IPV/Hib vaccine cost, discount & access