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Glass Ionomer
Glass ionomer is a dental restorative material that chemically bonds to tooth structure through an acid-base reaction between glass powder and polyacrylic acid.
Glass ionomer is a dental restorative material that chemically bonds to tooth structure through an acid-base reaction between glass powder and polyacrylic acid. Used for Dental restorations and fillings, Class III and V cavities, Luting agent for crowns and bridges.
At a glance
| Generic name | Glass Ionomer |
|---|---|
| Also known as | Fuji IX, GI |
| Sponsor | Ain Shams University |
| Modality | Small molecule |
| Therapeutic area | Dentistry |
| Phase | FDA-approved |
Mechanism of action
Glass ionomer cement forms a direct chemical bond with tooth enamel and dentin via an acid-base setting reaction. The polyacrylic acid component etches the tooth surface while simultaneously cross-linking with calcium and aluminum ions from the glass powder, creating a durable adhesive restoration. This material also releases fluoride ions, providing anticariogenic properties.
Approved indications
- Dental restorations and fillings
- Class III and V cavities
- Luting agent for crowns and bridges
- Pediatric dentistry applications
Common side effects
- Postoperative sensitivity
- Marginal discoloration
- Wear and abrasion
Key clinical trials
- Assessment of Alkasite Restorative Material Versus Resin Modified Glass Ionomer in Class V Cavities: A Clinical Trial (NA)
- Clinical Performance of a Novel Self-cured Resin Composite Compared to a Light-cured Bioactive Resin Composite Restoration in Proximal Cavities of Posterior Teeth (EARLY_PHASE1)
- Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis (PHASE1, PHASE2)
- Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth (PHASE4)
- Resin Infiltration vs Ionomer-Based Fluoride Varnish for the Prevention of Post-Eruptive Breakdown in Molars With Mild MIH (NA)
- Traditional vs. Minimally Invasive Decay Treatments in Primary Molars: An 18-month Split-mouth Randomized Study (NA)
- Gingival Health After Zirconia Versus Stainless Steel Crowns in Children (NA)
- Building Adaptive School-based Interventions for Caries (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Glass Ionomer CI brief — competitive landscape report
- Glass Ionomer updates RSS · CI watch RSS
- Ain Shams University portfolio CI