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Follitropin alfa and lutropin alfa
Follitropin alfa and lutropin alfa is a Gonadotropin Small molecule drug developed by D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology. It is currently FDA-approved for Infertility in women undergoing assisted reproductive technology (ART), Anovulation and ovulatory disorders in women. Also known as: Pergoveris, Follitropin alfa: Gonal-F or recombinant Follicle Stimulating Hormone (rFSH) and, Lutropin alfa: Luveris or Recombinant Luteinizing Hormone (rLH).
Follitropin alfa and lutropin alfa are recombinant gonadotropins that stimulate follicle development and ovulation in women undergoing assisted reproductive therapy.
Follitropin alfa and lutropin alfa are recombinant gonadotropins that stimulate follicle development and ovulation in women undergoing assisted reproductive therapy. Used for Infertility in women undergoing assisted reproductive technology (ART), Anovulation and ovulatory disorders in women.
At a glance
| Generic name | Follitropin alfa and lutropin alfa |
|---|---|
| Also known as | Pergoveris, Follitropin alfa: Gonal-F or recombinant Follicle Stimulating Hormone (rFSH) and, Lutropin alfa: Luveris or Recombinant Luteinizing Hormone (rLH) |
| Sponsor | D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology |
| Drug class | Gonadotropin |
| Target | FSH receptor and LH receptor |
| Modality | Small molecule |
| Therapeutic area | Reproductive/Fertility |
| Phase | FDA-approved |
Mechanism of action
Follitropin alfa (recombinant FSH) binds to follicle-stimulating hormone receptors on ovarian granulosa cells to promote follicular growth and estrogen production. Lutropin alfa (recombinant LH) acts on luteinizing hormone receptors to support androgen production and trigger the LH surge necessary for final oocyte maturation and ovulation. Together, they mimic the natural hormonal cascade required for controlled ovarian hyperstimulation in fertility treatment.
Approved indications
- Infertility in women undergoing assisted reproductive technology (ART)
- Anovulation and ovulatory disorders in women
Common side effects
- Ovarian hyperstimulation syndrome (OHSS)
- Headache
- Injection site reactions
- Abdominal pain/bloating
- Nausea
Key clinical trials
- An Ethno-bridging Study of Pergoveris in Healthy Premenopausal Participants of Japanese or Caucasian Origin (PHASE1)
- A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA) (PHASE3)
- Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation (PHASE2)
- Comparing IVF/ICSI Cycle Outcomes of Post Ovulation Ovarian Stimulation Protocol With Elonva Without GnRH Antagonist to Follicular Phase Day 2 Stimulation Fixed Day 5 Antagonist Protocol
- Extra Luteinizing Hormone Improve Embryo Quality in IVF Patients With Low LH During Long GnRH-Agonist Treatment (NA)
- Hormone Evaluation in Artificial Reproductive Technology (NA)
- Estradiol and Progesterone Levels Following Frozen Embryo Transfer (PHASE4)
- Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05693 (P05713)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Follitropin alfa and lutropin alfa CI brief — competitive landscape report
- Follitropin alfa and lutropin alfa updates RSS · CI watch RSS
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology portfolio CI
Frequently asked questions about Follitropin alfa and lutropin alfa
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Related
- Drug class: All Gonadotropin drugs
- Target: All drugs targeting FSH receptor and LH receptor
- Manufacturer: D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology — full pipeline
- Therapeutic area: All drugs in Reproductive/Fertility
- Indication: Drugs for Infertility in women undergoing assisted reproductive technology (ART)
- Indication: Drugs for Anovulation and ovulatory disorders in women
- Also known as: Pergoveris, Follitropin alfa: Gonal-F or recombinant Follicle Stimulating Hormone (rFSH) and, Lutropin alfa: Luveris or Recombinant Luteinizing Hormone (rLH)
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