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Folic acid, vit B12
Folic acid and vitamin B12 work together to support DNA synthesis, cell division, and red blood cell formation, with particular importance during pregnancy for fetal development.
Folic acid and vitamin B12 work together to support DNA synthesis, cell division, and red blood cell formation, with particular importance during pregnancy for fetal development. Used for Pregnancy supplementation for prevention of neural tube defects, Prevention of megaloblastic anemia in pregnancy, Maternal nutritional support during pregnancy and lactation.
At a glance
| Generic name | Folic acid, vit B12 |
|---|---|
| Sponsor | AGUNCO Obstetrics and Gynecology Centre |
| Drug class | Vitamin supplement combination |
| Modality | Small molecule |
| Therapeutic area | Obstetrics and Gynecology / Nutritional supplementation |
| Phase | FDA-approved |
Mechanism of action
Folic acid (vitamin B9) is a coenzyme essential for one-carbon transfer reactions required for DNA and RNA synthesis, while vitamin B12 (cobalamin) is necessary for methylation reactions and proper neurological function. Together, they prevent megaloblastic anemia and reduce the risk of neural tube defects in the developing fetus. Both vitamins are critical cofactors in homocysteine metabolism.
Approved indications
- Pregnancy supplementation for prevention of neural tube defects
- Prevention of megaloblastic anemia in pregnancy
- Maternal nutritional support during pregnancy and lactation
Common side effects
- Gastrointestinal upset
- Allergic reactions (rare)
- Headache
Key clinical trials
- Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older
- Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment (NA)
- Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC Patients (PHASE2)
- A Study Evaluating Quality of Life Parameters Following Use of Emergen-C (PHASE4)
- Patient Blood Management in Cardiac Surgery (NA)
- A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV. (NA)
- Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls (NA)
- Validation of a Novel Functional Food Designed to Meet the Nutritional Needs of People Living With Parkinson's Disease (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Folic acid, vit B12 CI brief — competitive landscape report
- Folic acid, vit B12 updates RSS · CI watch RSS
- AGUNCO Obstetrics and Gynecology Centre portfolio CI