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Fluticasone Furoate Inhalation Powder
Fluticasone Furoate Inhalation Powder is a Inhaled corticosteroid Small molecule drug developed by GlaxoSmithKline. It is currently in Phase 3 development for Asthma maintenance treatment, Chronic obstructive pulmonary disease (COPD).
Fluticasone furoate is a corticosteroid that binds to glucocorticoid receptors in the lungs to reduce inflammation and suppress immune responses in the airways.
Fluticasone furoate is a corticosteroid that binds to glucocorticoid receptors in the lungs to reduce inflammation and suppress immune responses in the airways. Used for Asthma maintenance treatment, Chronic obstructive pulmonary disease (COPD).
At a glance
| Generic name | Fluticasone Furoate Inhalation Powder |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Inhaled corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Respiratory / Pulmonology |
| Phase | Phase 3 |
Mechanism of action
As an inhaled corticosteroid, fluticasone furoate acts locally in the respiratory tract by activating glucocorticoid receptors on immune cells and epithelial cells. This leads to decreased production of inflammatory mediators, reduced recruitment of inflammatory cells, and suppression of airway hyperresponsiveness. The furoate ester formulation provides enhanced potency and prolonged local activity compared to other fluticasone formulations.
Approved indications
- Asthma maintenance treatment
- Chronic obstructive pulmonary disease (COPD)
Common side effects
- Tremor
- Headache
- Palpitations
- Muscle cramps
- Throat irritation
Key clinical trials
- A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations (PHASE3)
- A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma (PHASE3)
- A Bronchoscopy Study to Assess the Effects of Inhaled Corticosteroids on Adult Healthy Volunteers (PHASE4)
- VENTURI (VENTilation Using Respiratory Imaging) (PHASE2)
- Study to Evaluate the Therapeutic Equivalence and Safety of Fluticasone Furoate and Vilanterol Inhalation Powder 100 mcg/25 mcg and BREO ELLIPTA 100 mcg/25 mcg in Participants With Asthma (PHASE3)
- To Evaluate Real-World Effectiveness of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol (FF/UMEC/VI) in a Single Inhaler (Trelegy Ellipta) in Participants With Symptomatic COPD (PHASE4)
- Outcomes of Once-Daily ICS/LABA/LAMA + PRN Respiratory Therapy Treatments in Hospitalized Patients With COPD Exacerbations (PHASE4)
- ACTIV-6: COVID-19 Study of Repurposed Medications (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fluticasone Furoate Inhalation Powder CI brief — competitive landscape report
- Fluticasone Furoate Inhalation Powder updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI
Frequently asked questions about Fluticasone Furoate Inhalation Powder
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Related
- Drug class: All Inhaled corticosteroid drugs
- Target: All drugs targeting Glucocorticoid receptor
- Manufacturer: GlaxoSmithKline — full pipeline
- Therapeutic area: All drugs in Respiratory / Pulmonology
- Indication: Drugs for Asthma maintenance treatment
- Indication: Drugs for Chronic obstructive pulmonary disease (COPD)
- Compare: Fluticasone Furoate Inhalation Powder vs similar drugs
- Pricing: Fluticasone Furoate Inhalation Powder cost, discount & access