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Fluoxetine + outpatient cognitive behavioral therapy
Fluoxetine increases serotonin availability in the brain while cognitive behavioral therapy teaches patients to identify and modify maladaptive thought patterns and behaviors.
Fluoxetine increases serotonin availability in the brain while cognitive behavioral therapy teaches patients to identify and modify maladaptive thought patterns and behaviors. Used for Major depressive disorder, Obsessive-compulsive disorder, Panic disorder.
At a glance
| Generic name | Fluoxetine + outpatient cognitive behavioral therapy |
|---|---|
| Also known as | Prozac |
| Sponsor | National Institute on Drug Abuse (NIDA) |
| Drug class | SSRI + psychotherapy combination |
| Target | Serotonin transporter (SERT) |
| Modality | Small molecule |
| Therapeutic area | Psychiatry / Mental Health |
| Phase | FDA-approved |
Mechanism of action
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that blocks the reuptake of serotonin at the synaptic cleft, increasing serotonin concentration and improving mood regulation. Cognitive behavioral therapy (CBT) is a structured psychotherapeutic intervention that helps patients recognize negative thought patterns and develop coping strategies. The combination leverages both pharmacological and behavioral approaches to treat psychiatric conditions more effectively than either modality alone.
Approved indications
- Major depressive disorder
- Obsessive-compulsive disorder
- Panic disorder
- Substance use disorders (in research/clinical settings)
Common side effects
- Nausea
- Headache
- Insomnia
- Sexual dysfunction
- Anxiety (initial)
- Tremor
Key clinical trials
- UCAN2: Uniting Couples in the Treatment of Anorexia Nervosa (NA)
- Substance Dependent Teens - Impact of Treating Depression Study 1 - 1 (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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