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Fluoride toothpaste
Fluoride ions strengthen tooth enamel by promoting remineralization and inhibiting bacterial acid production.
Fluoride ions strengthen tooth enamel by promoting remineralization and inhibiting bacterial acid production. Used for Dental caries prevention, Enamel remineralization.
At a glance
| Generic name | Fluoride toothpaste |
|---|---|
| Also known as | Prevident, Clinpro, signal toothpaste, Fluoride, Crest Cavity Protection toothpaste |
| Sponsor | CareQuest Institute for Oral Health |
| Drug class | Topical fluoride agent |
| Target | Tooth enamel hydroxyapatite; oral bacterial glycolytic enzymes |
| Modality | Small molecule |
| Therapeutic area | Dental/Oral Health |
| Phase | FDA-approved |
Mechanism of action
Fluoride toothpaste works through two primary mechanisms: it facilitates the incorporation of fluoride into hydroxyapatite crystals in tooth enamel, creating a more acid-resistant mineral structure (fluorapatite), and it inhibits glycolysis in oral bacteria, reducing their ability to produce acids that demineralize teeth. This dual action prevents dental caries and promotes remineralization of early enamel lesions.
Approved indications
- Dental caries prevention
- Enamel remineralization
Common side effects
- Dental fluorosis (mild, from ingestion during childhood)
- Tooth sensitivity
- Gingival irritation
Key clinical trials
- Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion (PHASE3)
- Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses. (PHASE4)
- Investigation of Colgate Dual Zinc Toothpaste as Compared to Colgate Cavity Protection Toothpaste in Controlling Plaque and Gingivitis (PHASE3)
- Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection Toothpaste (PHASE3)
- Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis. (PHASE3)
- The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis. (PHASE3)
- Dentinal Hypersensitivity Reduction Efficacy Study (PHASE3)
- Dentinal Hypersensitivity Reduction (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fluoride toothpaste CI brief — competitive landscape report
- Fluoride toothpaste updates RSS · CI watch RSS
- CareQuest Institute for Oral Health portfolio CI