Last reviewed 2026-04-20 · How we verify

fluoride only toothpaste

At a glance

Approved indications

No approved indications tracked.

Common side effects

No common side effects on file.

Key clinical trials

• A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health (NA)
• The Effect of Salvadora Persica (Miswak) Compared to Fluoridated Toothpaste on Children's Teeth Diagnosed With Molar-Incisor Hypomineralization (MIH): A Randomized Clinical Trial (NA)
• Clinical Study to Evaluate the Tooth Whitening Efficacy of a New NextGen In-office Whitening System (PHASE3)
• Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices (NA)
• Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period. (PHASE2, PHASE3)
• Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide in the Immediate Removal of Tooth Stains After a Single Brushing. (PHASE3)
• A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New Toothpaste (PHASE3)
• Evaluation of the Effect of a Probiotic in Patients Undergoing Orthodontic Therapy (NA)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• fluoride only toothpaste CI brief — competitive landscape report
• fluoride only toothpaste updates RSS · CI watch RSS
• Colgate Palmolive portfolio CI