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Fluorescéine Sodique Faure
Sodium fluorescein is a fluorescent dye that emits light when excited by specific wavelengths, enabling visualization of ocular structures and blood flow in diagnostic imaging.
Sodium fluorescein is a fluorescent dye that emits light when excited by specific wavelengths, enabling visualization of ocular structures and blood flow in diagnostic imaging. Used for Fluorescein angiography for retinal and choroidal vascular imaging, Detection of retinal vascular leakage and ischemia, Assessment of diabetic retinopathy and age-related macular degeneration.
At a glance
| Generic name | Fluorescéine Sodique Faure |
|---|---|
| Sponsor | Rennes University Hospital |
| Drug class | Fluorescent diagnostic dye |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology / Diagnostic Imaging |
| Phase | Phase 3 |
Mechanism of action
Sodium fluorescein is a small-molecule fluorescent tracer that absorbs blue light (around 494 nm) and emits green-yellow fluorescence (around 521 nm). It is used in ophthalmology and angiography to visualize retinal and choroidal blood vessels, detect leakage from damaged vessels, and assess tissue perfusion. The dye distributes through the bloodstream and highlights vascular abnormalities and tissue damage in real-time imaging.
Approved indications
- Fluorescein angiography for retinal and choroidal vascular imaging
- Detection of retinal vascular leakage and ischemia
- Assessment of diabetic retinopathy and age-related macular degeneration
Common side effects
- Nausea
- Vomiting
- Allergic reaction (rare)
- Yellow discoloration of skin and urine (transient)
Key clinical trials
- A Novel Intraoperative Fluorescence-guided System for Evaluating Margins During Breast-conserving Surgery for Breast Cancer (NA)
- Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunction (PHASE4)
- Tunlametinib Combination Therapy in KRAS-Mutated Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancer (PHASE2)
- Automated Applanation Tonometry - Updated (NA)
- Retinal Vessel Leakage in Cerebral Small Vessel Disease
- Neoadjuvant Tebentafusp for Uveal Melanoma (PHASE2)
- Prevention of Onset and Transition to an Advanced Form of Diabetic Retinopathy in Children (NA)
- Intraoperative Use of I.V. Sodium Fluorescein in Suspected CNS Tumors
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |