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Fludarabine, Busulfan, Thymoglobulin
Fludarabine, Busulfan, Thymoglobulin is a Purine analog, Alkylating agent, Monoclonal antibody Small molecule drug developed by The Korean Society of Pediatric Hematology Oncology. It is currently in Phase 2 development for Acute myeloid leukemia, Chronic lymphocytic leukemia, Kidney transplant rejection.
Fludarabine is a purine analog that interferes with DNA synthesis, Busulfan is an alkylating agent that cross-links DNA, and Thymoglobulin is a monoclonal antibody that depletes T-lymphocytes.
Fludarabine is a purine analog that interferes with DNA synthesis, Busulfan is an alkylating agent that cross-links DNA, and Thymoglobulin is a monoclonal antibody that depletes T-lymphocytes. Used for Acute myeloid leukemia, Chronic lymphocytic leukemia, Kidney transplant rejection.
At a glance
| Generic name | Fludarabine, Busulfan, Thymoglobulin |
|---|---|
| Sponsor | The Korean Society of Pediatric Hematology Oncology |
| Drug class | Purine analog, Alkylating agent, Monoclonal antibody |
| Target | DNA, CD3 receptors |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
Fludarabine works by incorporating itself into DNA and interfering with DNA synthesis, leading to cell death. Busulfan works by cross-linking DNA, which prevents cancer cells from replicating. Thymoglobulin works by binding to CD3 receptors on T-lymphocytes and marking them for destruction, leading to a decrease in T-cell count.
Approved indications
- Acute myeloid leukemia, Chronic lymphocytic leukemia, Kidney transplant rejection
Common side effects
- Nausea
- Vomiting
- Diarrhea
- Fatigue
- Infection
Key clinical trials
- Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders (PHASE2)
- Allo HSCT for High Risk Hemoglobinopathies (PHASE2)
- Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML (PHASE1, PHASE2)
- Study Comparing the Efficacy of 2 RIC Regimens (Clofarabine vs Fludarabine) in Adults With AML Eligible to Allo-SCT (PHASE2)
- Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation (PHASE2)
- Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes (PHASE2)
- Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome (PHASE3)
- HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fludarabine, Busulfan, Thymoglobulin CI brief — competitive landscape report
- Fludarabine, Busulfan, Thymoglobulin updates RSS · CI watch RSS
- The Korean Society of Pediatric Hematology Oncology portfolio CI
Frequently asked questions about Fludarabine, Busulfan, Thymoglobulin
What is Fludarabine, Busulfan, Thymoglobulin?
How does Fludarabine, Busulfan, Thymoglobulin work?
What is Fludarabine, Busulfan, Thymoglobulin used for?
Who makes Fludarabine, Busulfan, Thymoglobulin?
What drug class is Fludarabine, Busulfan, Thymoglobulin in?
What development phase is Fludarabine, Busulfan, Thymoglobulin in?
What are the side effects of Fludarabine, Busulfan, Thymoglobulin?
What does Fludarabine, Busulfan, Thymoglobulin target?
Related
- Drug class: All Purine analog, Alkylating agent, Monoclonal antibody drugs
- Target: All drugs targeting DNA, CD3 receptors
- Manufacturer: The Korean Society of Pediatric Hematology Oncology — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Acute myeloid leukemia, Chronic lymphocytic leukemia, Kidney transplant rejection
- Compare: Fludarabine, Busulfan, Thymoglobulin vs similar drugs
- Pricing: Fludarabine, Busulfan, Thymoglobulin cost, discount & access