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Flublok Quadrivalent Influenza Vaccine
Flublok Quadrivalent Influenza Vaccine is a Recombinant protein vaccine Biologic drug developed by Protein Sciences Corporation. It is currently in Phase 3 development for Prevention of influenza illness caused by influenza A and B viruses in adults 18 years and older.
Flublok Quadrivalent stimulates immune response against four influenza virus strains by presenting recombinant hemagglutinin antigens produced in insect cells.
Flublok Quadrivalent stimulates immune response against four influenza virus strains by presenting recombinant hemagglutinin antigens produced in insect cells. Used for Prevention of influenza illness caused by influenza A and B viruses in adults 18 years and older.
At a glance
| Generic name | Flublok Quadrivalent Influenza Vaccine |
|---|---|
| Sponsor | Protein Sciences Corporation |
| Drug class | Recombinant protein vaccine |
| Target | Influenza hemagglutinin (HA) antigen |
| Modality | Biologic |
| Therapeutic area | Immunology / Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
This vaccine uses recombinant DNA technology to produce hemagglutinin proteins from four influenza strains (two A subtypes and two B lineages) in cultured insect cells, rather than growing virus in eggs. The recombinant hemagglutinin antigens trigger both humoral and cellular immune responses, generating antibodies and T-cell immunity against the targeted influenza strains.
Approved indications
- Prevention of influenza illness caused by influenza A and B viruses in adults 18 years and older
Common side effects
- Injection site pain
- Injection site erythema
- Injection site swelling
- Myalgia
- Headache
- Fatigue
Key clinical trials
- Randomized Influenza Vaccine Evaluation of Immune Response (PHASE4)
- Immunogenicity Trial of 3 Influenza Vaccines (PHASE3)
- Flublok or Fluzone With Advax-CpG55.2 or AF03 (PHASE1)
- Substudy 01 - Safety and Immunogenicity of One Monovalent Modified mRNA Vaccine Encoding Influenza Hemagglutinin With LNP, in Adult Participants Aged 18 to 49 Years and 60 Years and Above (PHASE1)
- Study With Quadrivalent Recombinant Influenza Vaccine (RIV4) in Participants 9 Through 49 Years of Age. (PHASE3)
- Study With Quadrivalent Recombinant Influenza Vaccine (RIV4) Compared With Egg-Based Quadrivalent Influenza Vaccine (IIV4) in Participants Aged 3 to 8 Years (PHASE3)
- A Study to Investigate the Safety and Immunogenicity of the Quadrivalent Influenza mRNA Vaccines in Adults Aged 18 Years and Above (PHASE1, PHASE2)
- The Celljuvant Study: A Phase 3 Immunogenicity and Safety Study of aQIVc Vaccine in Adults Aged 50 Years and Older (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Flublok Quadrivalent Influenza Vaccine CI brief — competitive landscape report
- Flublok Quadrivalent Influenza Vaccine updates RSS · CI watch RSS
- Protein Sciences Corporation portfolio CI
Frequently asked questions about Flublok Quadrivalent Influenza Vaccine
What is Flublok Quadrivalent Influenza Vaccine?
How does Flublok Quadrivalent Influenza Vaccine work?
What is Flublok Quadrivalent Influenza Vaccine used for?
Who makes Flublok Quadrivalent Influenza Vaccine?
What drug class is Flublok Quadrivalent Influenza Vaccine in?
What development phase is Flublok Quadrivalent Influenza Vaccine in?
What are the side effects of Flublok Quadrivalent Influenza Vaccine?
What does Flublok Quadrivalent Influenza Vaccine target?
Related
- Drug class: All Recombinant protein vaccine drugs
- Target: All drugs targeting Influenza hemagglutinin (HA) antigen
- Manufacturer: Protein Sciences Corporation — full pipeline
- Therapeutic area: All drugs in Immunology / Infectious Disease
- Indication: Drugs for Prevention of influenza illness caused by influenza A and B viruses in adults 18 years and older
- Compare: Flublok Quadrivalent Influenza Vaccine vs similar drugs
- Pricing: Flublok Quadrivalent Influenza Vaccine cost, discount & access