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Fish oils
Fish oils provide omega-3 polyunsaturated fatty acids (EPA and DHA) that reduce inflammation and modulate lipid metabolism.
Fish oils provide omega-3 polyunsaturated fatty acids (EPA and DHA) that reduce inflammation and modulate lipid metabolism. Used for Hypertriglyceridemia, Cardiovascular disease prevention, Secondary prevention post-myocardial infarction.
At a glance
| Generic name | Fish oils |
|---|---|
| Sponsor | The University of Western Australia |
| Drug class | Omega-3 polyunsaturated fatty acid supplement |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Fish oils contain eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are incorporated into cell membranes and compete with arachidonic acid-derived pro-inflammatory mediators. These omega-3 fatty acids reduce triglycerides, lower blood pressure, and decrease platelet aggregation through multiple pathways including G-protein coupled receptor signaling and gene expression modulation.
Approved indications
- Hypertriglyceridemia
- Cardiovascular disease prevention
- Secondary prevention post-myocardial infarction
Common side effects
- Gastrointestinal upset (nausea, dyspepsia)
- Fishy aftertaste
- Bleeding or bruising (at high doses)
- Headache
Key clinical trials
- FAST for DM - Fatty Acid Supplementation Trial (FAST) for Dermatomyositis (DM) (PHASE2)
- Heart & Health Study (NA)
- Nutrition for Precision Health, Powered by the All of Us (NA)
- A Clinical Trial Via Telepsychiatry of Treatments for the Management of Emotional Dysregulation in Youth (PHASE4)
- Can People Achieve a Target Omega-3 Index by Following a Personalized Omega-3 Dosing Regimen? (NA)
- Effect of a Parenteral Emulsion With Omega3 on Neonates With PPHN and CDH (PHASE2)
- Impact of an Omega-3 Enriched Oral Nutritional Supplement on Improving Surgical Outcomes in Patients With Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery (NA)
- Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fish oils CI brief — competitive landscape report
- Fish oils updates RSS · CI watch RSS
- The University of Western Australia portfolio CI