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Fentanyl-TTS
Fentanyl-TTS is a transdermal patch that delivers the opioid fentanyl through the skin at a controlled rate to provide long-acting pain relief.
Fentanyl-TTS is a transdermal patch that delivers the opioid fentanyl through the skin at a controlled rate to provide long-acting pain relief. Used for Chronic pain in opioid-tolerant patients, Cancer pain, Severe chronic pain requiring opioid therapy.
At a glance
| Generic name | Fentanyl-TTS |
|---|---|
| Also known as | fentanyl |
| Sponsor | Janssen-Cilag, S.A. |
| Drug class | Opioid analgesic |
| Target | Mu (μ) opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Fentanyl is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central and peripheral nervous system, inhibiting pain signal transmission and producing analgesia. The transdermal therapeutic system (TTS) formulation allows continuous delivery of fentanyl over 72 hours, maintaining steady-state plasma concentrations and providing sustained pain control without frequent dosing.
Approved indications
- Chronic pain in opioid-tolerant patients
- Cancer pain
- Severe chronic pain requiring opioid therapy
Common side effects
- Nausea
- Constipation
- Dizziness
- Somnolence
- Headache
- Vomiting
- Application site reactions
Key clinical trials
- Traumatologic Acute Pain Management With Fentanyl Transdermal Therapeutic System (TTS) (PHASE3)
- Efficacy of Transdermal Fentanyl Patches in Relief of Acute Postoperative Pain After Mastectomy (PHASE4)
- An Efficacy and Safety Study of Low-dose Transdermal Therapeutic System (TTS)-Fentanyl D-Trans in Taiwan Participants With Cancer Pain (PHASE4)
- Efficacy and Safety Study of Fentanyl Transdermal Patch for Treatment of Chronic Pain (PHASE4)
- An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Cancer Participants With Inadequately Controlled Pain by Non-Narcotic Analgesics (PHASE4)
- An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Thai Participants With Chronic Non-Malignant Pain (PHASE4)
- Efficacy and Safety Study of Transdermal Therapeutic System (TTS) Fentanyl in Participants With Osteoarthritis Knee Pain (PHASE4)
- An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Participants With Osteoarthritis (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fentanyl-TTS CI brief — competitive landscape report
- Fentanyl-TTS updates RSS · CI watch RSS
- Janssen-Cilag, S.A. portfolio CI