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Fentanyl Plus Midazolam
Fentanyl is an opioid agonist that binds mu receptors to provide analgesia and sedation, while midazolam is a benzodiazepine that enhances GABAergic inhibition in the central nervous system for anxiolysis and sedation.
Fentanyl is an opioid agonist that binds mu receptors to provide analgesia and sedation, while midazolam is a benzodiazepine that enhances GABAergic inhibition in the central nervous system for anxiolysis and sedation. Used for Procedural sedation and analgesia, Palliative care and pain management.
At a glance
| Generic name | Fentanyl Plus Midazolam |
|---|---|
| Also known as | Sublimaze, Versed |
| Sponsor | Mount Carmel Health System |
| Drug class | Opioid agonist + benzodiazepine combination |
| Target | Mu opioid receptor (fentanyl); GABA-A receptor (midazolam) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia, Analgesia, Palliative Care |
| Phase | FDA-approved |
Mechanism of action
Fentanyl acts as a potent mu-opioid receptor agonist, blocking pain signal transmission and producing analgesia and respiratory depression. Midazolam potentiates inhibitory GABA neurotransmission, producing anxiolytic, sedative, and amnestic effects. Together, this combination provides enhanced analgesia and sedation for procedural or palliative use.
Approved indications
- Procedural sedation and analgesia
- Palliative care and pain management
Common side effects
- Respiratory depression
- Hypotension
- Sedation/drowsiness
- Nausea
- Dizziness
Key clinical trials
- HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids (NA)
- The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delivery Under Spinal Anesthesia (NA)
- Virtual Reality to Improve Patient Experience During Endoscopic Mucosal and Submucosal Resection (NA)
- Prospective IR-led Sedation Feasibility (PHASE1, PHASE2)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Comparison of Lumbar Erector Spinae Plane Block and Spinal Anesthesia in Hip and Proximal Femur Surgery (NA)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
- Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fentanyl Plus Midazolam CI brief — competitive landscape report
- Fentanyl Plus Midazolam updates RSS · CI watch RSS
- Mount Carmel Health System portfolio CI