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Fentanyl-Morphine
This is a combination of two opioid agonists that bind to mu-opioid receptors in the central nervous system to produce analgesia and sedation.
This is a combination of two opioid agonists that bind to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Acute postoperative pain, Severe acute pain requiring opioid analgesia.
At a glance
| Generic name | Fentanyl-Morphine |
|---|---|
| Sponsor | Seoul National University Hospital |
| Drug class | Opioid agonist combination |
| Target | Mu-opioid receptor (OPRM1) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Fentanyl is a potent synthetic opioid agonist, while morphine is a natural opioid alkaloid; both work by activating mu-opioid receptors to modulate pain perception and produce analgesia. The combination may be used to optimize pain control through complementary pharmacokinetic profiles, with fentanyl providing rapid onset and morphine providing sustained duration. This dual-agent approach is typically employed in acute or perioperative pain management settings.
Approved indications
- Acute postoperative pain
- Severe acute pain requiring opioid analgesia
Common side effects
- Respiratory depression
- Sedation
- Nausea
- Hypotension
- Pruritus
Key clinical trials
- Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine (PHASE3)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Quality of Postoperative Analgesia and Functional Recovery After Elective Cesarean Delivery (NA)
- Effect of Intraoperative Morphine on Postoperative Pain After CABG (PHASE4)
- Symptom-inhibited Fentanyl Induction (PHASE4)
- General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia (NA)
- Effectiveness of Percutaneous Neuromodulation vs Pharmacological Treatment in Cancer Patients With Anterior Knee Pain (NA)
- Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fentanyl-Morphine CI brief — competitive landscape report
- Fentanyl-Morphine updates RSS · CI watch RSS
- Seoul National University Hospital portfolio CI