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Fentanyl demand
Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.
Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Acute and chronic pain management, Cancer pain, Perioperative analgesia.
At a glance
| Generic name | Fentanyl demand |
|---|---|
| Also known as | Abstral, Actiq, Fentora, Onsolis |
| Sponsor | University of Pennsylvania |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (OPRM1) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Fentanyl activates mu-opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and producing potent analgesic and euphoric effects. It is approximately 50-100 times more potent than morphine. The term 'Fentanyl demand' likely refers to a demand-controlled or patient-controlled analgesia (PCA) delivery system rather than a novel drug entity.
Approved indications
- Acute and chronic pain management
- Cancer pain
- Perioperative analgesia
Common side effects
- Respiratory depression
- Nausea and vomiting
- Constipation
- Dizziness
- Sedation
- Pruritus
Key clinical trials
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Development of Variable Volume Automated Mandatory Boluses for Patient-controlled Epidural Analgesia During Labour (PHASE3)
- Parturient Satisfaction With Epidural Analgesia by PCEA or Manual Boluses
- Position and Predictive Factors of Hypotension in Prone Percutaneous Nephrolithotomy
- Study of SyB P-1501 (Fentanyl HCI) for Treatment of Postoperative Pain (PHASE3)
- Epidural Morphine Versus Epidural Fentanyl Infusion Following Cesarean Section (NA)
- Nociception-directed Erector Muscle Spinae Plane Block in Open Heart Surgery (PHASE4)
- Modeling and Application of Triple Drug Response Surface Models
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fentanyl demand CI brief — competitive landscape report
- Fentanyl demand updates RSS · CI watch RSS
- University of Pennsylvania portfolio CI