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Fentanyl and Propofol
Fentanyl and Propofol is a Opioid agonist + sedative-hypnotic combination Small molecule drug developed by Jiangsu Hengrui Pharmaceutical Co., Ltd.. It is currently FDA-approved for Induction and maintenance of general anesthesia, Sedation in intensive care units, Procedural sedation.
Fentanyl is an opioid agonist that binds mu opioid receptors to provide analgesia, while propofol is a sedative-hypnotic that enhances GABA inhibitory neurotransmission to induce unconsciousness.
Propofol is a small molecule that acts as a positive allosteric modulator of the GABA-A receptor, an anion channel. It is used in general anesthesia and has been studied in various clinical trials for conditions such as perioperative pain management and fluid management during elective spine surgeries. Fentanyl is not mentioned in the provided facts, but Propofol is.
At a glance
| Generic name | Fentanyl and Propofol |
|---|---|
| Sponsor | Jiangsu Hengrui Pharmaceutical Co., Ltd. |
| Drug class | Opioid agonist + sedative-hypnotic combination |
| Target | Mu opioid receptor (fentanyl); GABA-A receptor (propofol) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
This is a combination product used for anesthesia and sedation. Fentanyl acts as a potent mu opioid receptor agonist, providing rapid-onset analgesia and contributing to anesthetic depth. Propofol is an intravenous sedative-hypnotic that potentiates GABA-A receptor signaling, producing sedation, hypnosis, and amnesia. Together, they provide balanced anesthesia with analgesia and hypnosis.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in intensive care units
- Procedural sedation
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Injection site pain
- Nausea and vomiting
- Apnea
Key clinical trials
- Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy (PHASE4)
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives (NA)
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- THRIVE in Sedated Gastrointestinal Endoscopy
- General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia (NA)
- General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fentanyl and Propofol CI brief — competitive landscape report
- Fentanyl and Propofol updates RSS · CI watch RSS
- Jiangsu Hengrui Pharmaceutical Co., Ltd. portfolio CI
Frequently asked questions about Fentanyl and Propofol
What is Fentanyl and Propofol?
How does Fentanyl and Propofol work?
What is Fentanyl and Propofol used for?
Who makes Fentanyl and Propofol?
What drug class is Fentanyl and Propofol in?
What development phase is Fentanyl and Propofol in?
What are the side effects of Fentanyl and Propofol?
What does Fentanyl and Propofol target?
Related
- Drug class: All Opioid agonist + sedative-hypnotic combination drugs
- Target: All drugs targeting Mu opioid receptor (fentanyl); GABA-A receptor (propofol)
- Manufacturer: Jiangsu Hengrui Pharmaceutical Co., Ltd. — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for Induction and maintenance of general anesthesia
- Indication: Drugs for Sedation in intensive care units
- Indication: Drugs for Procedural sedation
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing