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Fentanyl and bupivacaine
Fentanyl is a potent opioid agonist that binds mu opioid receptors to provide analgesia, while bupivacaine is a local anesthetic that blocks sodium channels to prevent nerve signal transmission.
Fentanyl is a potent opioid agonist that binds mu opioid receptors to provide analgesia, while bupivacaine is a local anesthetic that blocks sodium channels to prevent nerve signal transmission. Used for Regional anesthesia and analgesia, Perioperative pain management, Local infiltration anesthesia with systemic analgesia.
At a glance
| Generic name | Fentanyl and bupivacaine |
|---|---|
| Sponsor | Hospital Central Dr. Luis Ortega |
| Drug class | Opioid analgesic combined with local anesthetic |
| Target | Mu opioid receptor (fentanyl); voltage-gated sodium channels (bupivacaine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
This is a combination product where fentanyl acts systemically as an opioid analgesic for pain relief, and bupivacaine acts locally at the site of administration by blocking voltage-gated sodium channels in nerve fibers, preventing action potential propagation. Together they provide both systemic and local anesthesia/analgesia, commonly used in regional anesthesia and pain management procedures.
Approved indications
- Regional anesthesia and analgesia
- Perioperative pain management
- Local infiltration anesthesia with systemic analgesia
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea
- Dizziness
- Local tissue irritation
Key clinical trials
- Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures (NA)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Liver Resection Surgery (NA)
- Quality of Postoperative Analgesia and Functional Recovery After Elective Cesarean Delivery (NA)
- Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine (PHASE4)
- Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery (PHASE3)
- Epidural vs. Dural Puncture Epidural in Labor Analgesia (NA)
- Maternal Satisfaction After Spinal Anesthesia for Cesarean Delivery
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fentanyl and bupivacaine CI brief — competitive landscape report
- Fentanyl and bupivacaine updates RSS · CI watch RSS
- Hospital Central Dr. Luis Ortega portfolio CI