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EV71 (inoculation vaccine)
EV71 vaccine stimulates the immune system to produce antibodies and cellular immunity against Enterovirus 71, preventing infection and disease.
EV71 vaccine stimulates the immune system to produce antibodies and cellular immunity against Enterovirus 71, preventing infection and disease. Used for Prevention of Enterovirus 71 infection and hand, foot, and mouth disease (HFMD).
At a glance
| Generic name | EV71 (inoculation vaccine) |
|---|---|
| Sponsor | Shandong Province Centers for Disease Control and Prevention |
| Drug class | inactivated viral vaccine |
| Target | Enterovirus 71 (EV71) viral antigens |
| Modality | Biologic |
| Therapeutic area | Immunology / Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
The vaccine contains inactivated or attenuated EV71 virus particles that trigger both humoral (antibody) and cell-mediated immune responses. Upon exposure to wild-type EV71, the primed immune system recognizes and neutralizes the virus, preventing viral replication and the development of hand, foot, and mouth disease (HFMD) and its severe neurological complications.
Approved indications
- Prevention of Enterovirus 71 infection and hand, foot, and mouth disease (HFMD)
Common side effects
- Injection site pain, erythema, or swelling
- Fever
- Myalgia or fatigue
Key clinical trials
- Study on the Persistence of Immunity Following EV71 Vaccination
- Clinical Trial for Batch Consistency of EV71 Vaccine (PHASE4)
- A Study to Evaluate the Efficacy, Immunogenicity and Safety of an EV71 Vaccine in Healthy Infants and Children (PHASE3)
- Immunogenicity of the Inactivated EV71 Vaccine Combined With Hepatitis B and Group A Meningococcal Vaccine (PHASE4)
- Immunogenicity And Safety of COVID-19 Vaccine , Inactivated Co -Administration With EV71 Vaccine (Vero Cell) (PHASE4)
- Immunogenicity And Safety of COVID-19 Vaccine , Inactivated Co -Administration With EV71 Vaccine (Vero Cell) (PHASE4)
- The Immunogenicity and Safety of the Vaccination of Inactivated Enterovirus 71 Vaccine and Seasonal Influenza Vaccine (PHASE4)
- Safety Observation of Enterovirus 71 Inactivated Vaccine (Vero Cell) Combined Immunization in Shanghai
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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