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Euthyrox (levothyroxine)
Levothyroxine is a synthetic thyroid hormone that replaces or supplements endogenous thyroid hormone to restore normal thyroid function.
Levothyroxine is a synthetic thyroid hormone that replaces or supplements endogenous thyroid hormone to restore normal thyroid function. Used for Hypothyroidism, Thyroid cancer suppression therapy, Myxedema coma.
At a glance
| Generic name | Euthyrox (levothyroxine) |
|---|---|
| Also known as | Euthyrox/levothyroxine |
| Sponsor | University Medical Center Groningen |
| Drug class | Thyroid hormone replacement |
| Target | Thyroid hormone receptors (TR-alpha and TR-beta) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology |
| Phase | FDA-approved |
Mechanism of action
Levothyroxine is a synthetic form of thyroxine (T4), a hormone produced by the thyroid gland. It binds to thyroid hormone receptors in target tissues and is peripherally converted to the more active T3 form, increasing metabolic rate and regulating energy production, protein synthesis, and cellular function. This restores euthyroid state in patients with hypothyroidism or thyroid hormone deficiency.
Approved indications
- Hypothyroidism
- Thyroid cancer suppression therapy
- Myxedema coma
- Thyroid hormone replacement after thyroidectomy or radioactive iodine therapy
Common side effects
- Tachycardia
- Tremor
- Anxiety
- Insomnia
- Heat intolerance
- Weight loss
- Palpitations
Key clinical trials
- Novel Approaches to the Treatment of Hypothyroidism (PHASE2, PHASE3)
- Comparison of Levothyroxine Formulations in the Treatment of Congenital Hypothyroidism
- Neuroendocrine Response in Pediatric Febrile Seizures
- T4/T3 Therapy in Hypothyroidism (PHASE2)
- SNUH Immune Checkpoint Inhibitor-induced Hypothyroidism Recovery Trial (NA)
- Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in Veterans (PHASE2)
- Dosing of LT4 in Older Individuals (PHASE4)
- A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in Patients With Primary Hypothyroidism (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Euthyrox (levothyroxine) CI brief — competitive landscape report
- Euthyrox (levothyroxine) updates RSS · CI watch RSS
- University Medical Center Groningen portfolio CI