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Etomidate Injectable Emulsion
Etomidate is a rapid-acting intravenous anesthetic that enhances GABAergic inhibitory neurotransmission in the central nervous system.
Etomidate is a rapid-acting intravenous anesthetic that enhances GABAergic inhibitory neurotransmission in the central nervous system. Used for Induction of general anesthesia, Sedation in intensive care settings.
At a glance
| Generic name | Etomidate Injectable Emulsion |
|---|---|
| Sponsor | Hunan Kelun Pharmaceutical Co., Ltd. |
| Drug class | GABA-A receptor positive allosteric modulator; general anesthetic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Etomidate acts as a positive allosteric modulator of GABA-A receptors, increasing the frequency of chloride channel opening and hyperpolarizing neuronal membranes. This results in rapid onset of unconsciousness suitable for induction of general anesthesia. The emulsion formulation improves tolerability and reduces injection site pain compared to traditional formulations.
Approved indications
- Induction of general anesthesia
- Sedation in intensive care settings
Common side effects
- Injection site pain
- Transient apnea
- Hypotension
- Adrenocortical suppression
- Myoclonic movements
Key clinical trials
- A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of KL0011034 Injection in Healthy Volunteers (PHASE1)
- Safety and Efficacy of Maintenance of Etomidate in General Anesthesia (PHASE4)
- A Trial to Evaluate the Efficacy and Safety of Methoxyetomidate Hydrochloride for Injection (ET-26) for the Induction of General Anesthesia in Elective Surgery Subjects (PHASE3)
- Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus (PHASE4)
- Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia (PHASE4)
- Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children (PHASE4)
- Combined Use of Etomidate and Propofol in Painless Gastroscopy. (PHASE4)
- Etomidate Emulsion for Sedation in Patients Scheduled for Upper Gastrointestinal (GI) Endoscopy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Etomidate Injectable Emulsion CI brief — competitive landscape report
- Etomidate Injectable Emulsion updates RSS · CI watch RSS
- Hunan Kelun Pharmaceutical Co., Ltd. portfolio CI