Last reviewed · How we verify
estrogens
At a glance
| Generic name | estrogens |
|---|---|
| Also known as | Estradiol |
| Sponsor | National Heart, Lung, and Blood Institute (NHLBI) |
| Modality | Small molecule |
| Therapeutic area | Other |
| Phase | discontinued |
Approved indications
Boxed warnings
- WARNINGS 1. ESTROGENS HAVE BEEN REPORTED TO INCREASE THE RISK OF ENDOMETRIAL CARCINOMA Three independent case control studies have reported an increased risk of endometrial cancer in postmenopausal women exposed to exogenous estrogens for prolonged periods. 1-3 This risk was independent of the other known risk factors for endometrial cancer. These studies are further supported by the finding that incidence rates of endometrial cancer have increased sharply since 1969 in eight different areas of
Common side effects
Key clinical trials
- A Phase 3, Randomized, Three-Cycle, Double-Blind, Placebo-Controlled Study to Evaluate Induction of Secretory Conversion of Endometrium and Withdrawal Bleeding After Administration of TX-12-002-HR in (Phase 3)
- S-Equol in Alzheimer's Disease 2 (SEAD2) Trial (Phase 1)
- Oral Aromatase Inhibitors Modify the Gut Microbiome Effecting Estrogen Bioavailability (N/A)
- Chronobiologic Effects of Gonadal Steroid Manipulations in Volunteer Subjects (N/A)
- A Pilot Trial to Correlate Serum Levels of Calgranulin A and B With Estrogen Receptor Status Among Patients With Breast Cancer (N/A)
- Regulation of Cortisol Metabolism and Fat Patterning (NA)
- Association Between Fuchs' Endothelial Corneal Dystrophy Severity and Estrogen Exposure (N/A)
- The Relative Effects of Androgen, Estrogen, and the Combination of Androgen and Estrogen on Growth Rate, GH Binding Protein, IGF-I, and Cognitive Function in Growth Hormone-Treated Girls With Turner S (Phase 2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |