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Esomeprazole IV
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly blocking the H+/K+-ATPase enzyme in gastric parietal cells.
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly blocking the H+/K+-ATPase enzyme in gastric parietal cells. Used for Gastroesophageal reflux disease (GERD), Peptic ulcer disease, Zollinger-Ellison syndrome.
At a glance
| Generic name | Esomeprazole IV |
|---|---|
| Sponsor | AstraZeneca |
| Drug class | Proton pump inhibitor (PPI) |
| Target | H+/K+-ATPase (proton pump) |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | Phase 3 |
Mechanism of action
Esomeprazole is the active S-enantiomer of omeprazole. It binds to and inactivates the proton pump (H+/K+-ATPase) on the secretory surface of gastric parietal cells, preventing the final step of gastric acid production. This results in profound and sustained reduction of both basal and stimulated gastric acid secretion, providing rapid symptom relief and promoting healing of acid-related lesions.
Approved indications
- Gastroesophageal reflux disease (GERD)
- Peptic ulcer disease
- Zollinger-Ellison syndrome
- Prevention of NSAID-induced ulcers
- Stress ulcer prophylaxis in critically ill patients
Common side effects
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Constipation
- Hypomagnesemia (with long-term use)
- C. difficile infection (with long-term use)
Key clinical trials
- PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers (PHASE4)
- Efficacy and Safety of Esomeprazole 40 mg IV in Post-Surgical Patients Admitted to the ICU
- Phase II Clinical Study of Vonorasan Fumarate Injection in the Treatment of Peptic Ulcer Bleeding (PHASE2)
- A Study to Learn How a Proton Pump Inhibitor Affects the Way Elinzanetant (BAY 3427080) Moves Into, Through and Out of the Body, and How Much of it Gets Absorbed by the Body When Taken as a Single and Small Radioactive Dose in Healthy Adults (PHASE1)
- Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy (NA)
- Doppler-guided Endoscopic Treatment in Peptic Ulcer Bleeding (NA)
- Pilot Study To Investigate The Association Between Acid Control And Heartburn Symptoms After Proton Pump Inhibitor Treatment (PHASE4)
- Stress Ulcer Prophylaxis of Intravenous Esomeprazole in Chinese Seriously Ill Patients (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |