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ESMOLOL HYDROCHLORIDE
Esmolol selectively blocks beta 1 adrenergic receptors in the heart, with rapid onset and short duration.
At a glance
| Generic name | ESMOLOL HYDROCHLORIDE |
|---|---|
| Target | beta 1 receptors, beta 2 receptors |
| Modality | Small molecule |
| Phase | FDA-approved |
| First approval | 1986 |
Mechanism of action
Esmolol is a cardioselective beta-blocker that primarily targets beta 1 receptors in the heart, reducing heart rate and contractility. At higher doses, it can also affect beta 2 receptors in the lungs and blood vessels.
Approved indications
Common side effects
- hypotension
- asymptomatic hypotension
- symptomatic hypotension (hyperhidrosis, dizziness)
- infusion site reactions (inflammation and induration)
- nausea
- dizziness
- somnolence
Key clinical trials
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- POCUS-Guided Esmolol in Septic Shock: A Pilot RCT (PHASE1, PHASE2)
- Effect of MGRNOX-Guided General Anesthesia on Opioid Consumption in Patients (NA)
- Esmolol Versus Sufentanil on the Quality of Post-cholecystectomy Recovery Laparoscopic Anaesthesia With Orotracheal Intubation on an Outpatient Basis (PHASE4)
- Reduction of Edema With a Specialized Cocktail for Ultra-early Management in Intracerebral Hemorrhage (PHASE3)
- Age Comparisons of Exercising Muscle O2 Supply in Healthy Adults: Effects of Esmolol Infusion (EARLY_PHASE1)
- Opioids Continue to Play a Primary Role in the Management of Perioperative Pain Due to Opioid-Free Anesthesia in Open Heart Surgery.
- Effect of Opioid-free Anaesthesia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ESMOLOL HYDROCHLORIDE CI brief — competitive landscape report
- ESMOLOL HYDROCHLORIDE updates RSS · CI watch RSS