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Benzamycin (Erythromycin Lactobionate)
Benzamycin (Erythromycin Lactobionate) is a macrolide antibiotic developed by Arbor Pharmas LLC and currently owned by Hospira. It targets the potassium voltage-gated channel subfamily H member 2 and is used to treat various bacterial infections, including acne, sinusitis, and pneumonia. Benzamycin is a small molecule modality that has been FDA-approved since 1964 and is now off-patent with multiple generic manufacturers. It has a relatively short half-life of 2.0 hours and bioavailability of 35%. As an off-patent medication, Benzamycin is widely available in the market.
At a glance
| Generic name | Erythromycin Lactobionate |
|---|---|
| Sponsor | Pfizer |
| Drug class | Macrolide |
| Target | Potassium voltage-gated channel subfamily H member 2 |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | FDA-approved |
| First approval | 1964 |
Approved indications
- Acne vulgaris
- Acute bacterial sinusitis
- Acute gonococcal cervicitis
- Acute gonococcal endometritis
- Acute gonococcal urethritis
- Acute otitis media
- Bacterial pneumonia
- Chlamydia Cervicitis
- Chlamydial conjunctivitis
- Chlamydial pneumonia
- Diphtheria
- Erythrasma
- Gonorrhea
- Gonorrhea of rectum
- Haemophilus Influenzae Acute Otitis Media
- Infection due to Staphylococcus aureus
- Infection of skin AND/OR subcutaneous tissue
- Infective otitis media
- Legionnaires' Disease
- Listeriosis
Common side effects
- ocular irritations
- redness
- hypersensitivity reactions
Drug interactions
- High Risk QT Prolonging Agents
- P-glycoprotein Substrates
- disopyramide
- droperidol
- eszopiclone
- felodipine
- fentanyl
- fosamprenavir
- gatifloxacin
- gemifloxacin
- halofantrine
- indinavir
Key clinical trials
- ANTERO-4: VIPUN Gastric Monitoring System in an Erythromycin Model (NA)
- Safety and Efficacy of Solithromycin in Adolescents and Children With Community-Acquired Bacterial Pneumonia (PHASE2,PHASE3)
- Relationship Between Gastric Emptying and Glycemic Variability in Type 1 Diabetes Mellitus (PHASE1)
- Effect of the Motilin Receptor Agonist, Erythromycin, on Hunger and Food Intake; Study of Role of Cholinergic Pathways (NA)
- Intravenous Erythromycin Before Endoscopy in Patients With Variceal Bleeding: A Randomized, Double-Blind Trial (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |