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Ergocalciferol 50000 UNT

University of Alabama at Birmingham · FDA-approved active Small molecule

Ergocalciferol (vitamin D2) is converted in the body to its active form, which regulates calcium and phosphate absorption and homeostasis.

Ergocalciferol (vitamin D2) is converted in the body to its active form, which regulates calcium and phosphate absorption and homeostasis. Used for Vitamin D deficiency, Hypoparathyroidism, Rickets.

At a glance

Generic nameErgocalciferol 50000 UNT
SponsorUniversity of Alabama at Birmingham
Drug classVitamin D supplement
TargetVitamin D receptor (VDR)
ModalitySmall molecule
Therapeutic areaEndocrinology / Nutritional deficiency
PhaseFDA-approved

Mechanism of action

Ergocalciferol is a fat-soluble vitamin that is metabolized in the liver to 25-hydroxyvitamin D2 and then in the kidneys to the active form 1,25-dihydroxyvitamin D2. This active metabolite acts as a hormone, binding to vitamin D receptors in the intestines, bones, and kidneys to promote calcium absorption, maintain serum calcium and phosphate levels, and support bone mineralization and immune function.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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