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epirubicin , pirarubicin , hydroxycamptothecin and fluorouracil
epirubicin , pirarubicin , hydroxycamptothecin and fluorouracil is a anthracycline and antimetabolite chemotherapeutic agents Small molecule drug developed by Sun Yat-sen University. It is currently in Phase 3 development for Metastatic breast cancer, Metastatic colorectal cancer, Metastatic gastric cancer. Also known as: epirubicin，pirarubicin，hydroxycamptothecin or fluorouracil.
Epirubicin, pirarubicin, and fluorouracil are anthracycline and antimetabolite chemotherapeutic agents that work by inhibiting DNA synthesis and inducing DNA damage, leading to cell death.
Epirubicin, pirarubicin, and fluorouracil are anthracycline and antimetabolite chemotherapeutic agents that work by inhibiting DNA synthesis and inducing DNA damage, leading to cell death. Used for Metastatic breast cancer, Metastatic colorectal cancer, Metastatic gastric cancer.
At a glance
| Generic name | epirubicin , pirarubicin , hydroxycamptothecin and fluorouracil |
|---|---|
| Also known as | epirubicin，pirarubicin，hydroxycamptothecin or fluorouracil |
| Sponsor | Sun Yat-sen University |
| Drug class | anthracycline and antimetabolite chemotherapeutic agents |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Epirubicin and pirarubicin are anthracyclines that intercalate DNA strands, inhibiting the enzyme topoisomerase II and inducing DNA damage. Fluorouracil is an antimetabolite that inhibits thymidylate synthase, leading to the accumulation of toxic metabolites and DNA damage. Hydroxycamptothecin is a topoisomerase I inhibitor that blocks the enzyme's ability to repair DNA damage, leading to cell death.
Approved indications
- Metastatic breast cancer
- Metastatic colorectal cancer
- Metastatic gastric cancer
Common side effects
- Myelosuppression
- Cardiotoxicity
- Nausea and vomiting
- Diarrhea
- Fatigue
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- epirubicin , pirarubicin , hydroxycamptothecin and fluorouracil CI brief — competitive landscape report
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- Sun Yat-sen University portfolio CI
Frequently asked questions about epirubicin , pirarubicin , hydroxycamptothecin and fluorouracil
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What is epirubicin , pirarubicin , hydroxycamptothecin and fluorouracil used for?
Who makes epirubicin , pirarubicin , hydroxycamptothecin and fluorouracil?
Is epirubicin , pirarubicin , hydroxycamptothecin and fluorouracil also known as anything else?
What drug class is epirubicin , pirarubicin , hydroxycamptothecin and fluorouracil in?
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Related
- Drug class: All anthracycline and antimetabolite chemotherapeutic agents drugs
- Manufacturer: Sun Yat-sen University — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Metastatic breast cancer
- Indication: Drugs for Metastatic colorectal cancer
- Indication: Drugs for Metastatic gastric cancer
- Also known as: epirubicin，pirarubicin，hydroxycamptothecin or fluorouracil
- Compare: epirubicin , pirarubicin , hydroxycamptothecin and fluorouracil vs similar drugs
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